312272-59-6 Usage
Uses
Used in Pharmaceutical Synthesis:
5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-amine is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity allow for the development of new therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Production:
In the agrochemical sector, 5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-amine is employed as a building block for the creation of novel agrochemicals. Its incorporation into these products can enhance their effectiveness in controlling pests and diseases, thereby contributing to increased crop yields and food security.
Used in Organic Synthesis:
5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-amine is utilized as a versatile reagent in organic synthesis, enabling the formation of a wide range of chemical compounds. Its presence in various synthetic pathways underscores its importance in the field of organic chemistry.
Used in Drug Development:
Due to its potential biological activities, 5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-amine is studied for its role in drug development. Its antifungal and antibacterial properties are of particular interest, as they may lead to the discovery of new treatments for infectious diseases.
Used in Research and Development:
In the realm of research and development, 5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-amine serves as a valuable compound for exploring new chemical reactions and understanding the underlying mechanisms. Its unique properties make it an attractive candidate for advancing scientific knowledge and fostering innovation in chemical and biological disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 312272-59-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,2,7 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 312272-59:
(8*3)+(7*1)+(6*2)+(5*2)+(4*7)+(3*2)+(2*5)+(1*9)=106
106 % 10 = 6
So 312272-59-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN3O/c9-6-4-2-1-3-5(6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)
312272-59-6Relevant articles and documents
Synthesis of 1,3,4-oxadiazoles as selective T-type calcium channel inhibitors
Zhang, Man,Zou, Bende,Gunaratna, Medha J.,Weerasekara, Sahani,Tong, Zongbo,Nguyen, Thi D.T.,Koldas, Serkan,Cao, William S.,Pascual, Conrado,Xie, Xinmin Simon,Hua, Duy H.
, p. 145 - 164 (2020/02/04)
– Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca2+ concentration through a dysfunction of T-type Ca2+ channels. Thus, T-type calcium channels could be a target in drug discovery for the treatments of neuropathic pain and epilepsy. From rational drug design approach, a group of 2,5-disubstituted 1,3,4-oxadiazole molecules was synthesized and their selective T-type channel inhibitions were evaluated. The synthetic strategy consists of a short sequence of three reactions: (i) condensation of thiosemicarbazide with acid chlorides; (ii) ring closing by 1,3-dibromo-5,5-dimethylhydantoin; and (iii) coupling with various acid chlorides. 5-Chloro-N-(5-phenyl-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide (11) was found to selectively inhibit T-type Ca2+ channel over Na+ and K+ channels in mouse dorsal root ganglion neurons and/or human embryonic kidney (HEK)-293 cells and to suppress seizure-induced death in mouse model. Consequently, compound 11 is a useful probe for investigation of physiologic and pathophysiologic roles of the T-channel, and provides a basis to develop a novel therapeutic to treat chronic neuropathic and inflammatory pains.
