312299-30-2Relevant academic research and scientific papers
Microtubule destabilizing sulfonamides as an alternative to taxane-based chemotherapy
González, Myriam,Ovejero-Sánchez, María,Vicente-Blázquez, Alba,álvarez, Raquel,Herrero, Ana B.,Medarde, Manuel,González-Sarmiento, Rogelio,Peláez, Rafael
, p. 1 - 21 (2021)
Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most com-monly diagnosed and responsible for most cancer deaths in women. The high incidence and mortality of these malignancies, together with the handicaps of taxanes —first-l
Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement
Yang, Di,Xie, Cai-Xia,Wu, Xiao-Tian,Fei, Luo-Ran,Feng, Lei,Ma, Chen
supporting information, p. 14905 - 14915 (2020/11/13)
A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.
4-Amino-5-(arylaminomethyl)-2-(methylthio)furo[2,3-d]pyrimidines via Mitsunobu reaction of 4-amino-5-(hydroxymethyl)-2-(methylthio)furo[2,3-d] pyrimidine with N-mesyl- and N-nosylarylamines
Masevicius, Viktoras,Petraityte, Grazina,Tumkevicius, Sigitas
experimental part, p. 1329 - 1338 (2012/07/01)
An efficient method for the synthesis of 4-amino-5-(arylaminomethyl)-2- (methylthio)furo[2,3-d]pyrimidines via the Mitsunobu reaction of 4-amino-5-(hydroxymethyl)-2-(methylthio)furo[2,3-d]pyrimidine with N-mesyl- and N-nosylarylamines, and subsequent removal of the mesyl and nosyl groups, has been developed. The influence of substituents in the arylamine moiety on the Mitsunobu reaction was investigated. An unexpected nucleophilic substitution of a nitro group in the reaction of N-({4-amino-2-(methylsulfonyl)furo[2,3-d] pyrimidin-5-yl}methyl)-4-nitro-N-phenylbenzenesulfonamide with sodium methoxide was observed. Georg Thieme Verlag Stuttgart · New York.
Cell proliferation inhibitors
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, (2008/06/13)
Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
