312305-95-6

Basic information

• Product Name: benzyl (2R)-5-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-2,3-dihydro-1H-indole-1-carboxylate
• CAS NO: 312305-95-6
• Molecular Weight: 423.469
• Mol File: 312305-95-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl (2R)-5-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-2,3-dihydro-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (2R)-5-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-2,3-dihydro-1H-indole-1-carboxylate(312305-95-6)
• EPA Substance Registry System: benzyl (2R)-5-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-2,3-dihydro-1H-indole-1-carboxylate(312305-95-6)

Safety Data

• Hazardous Substances Data: 312305-95-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 312306-01-7 benzyl (2R)-5-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-2,3-dihydro-1H-indole-1-carboxylate 
• 312305-90-1 benzyl 5-{[(benzyloxy)carbonyl]amino}-2-methyl-1-indolinecarboxylate 
• 312305-94-5 benzyl (2R)-5-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-2,3-dihydro-1H-indole-1-carboxylate 
• 7570-47-0 5-nitro-2-methylindole 
• 103796-38-9 2-methyl-indolin-5-ylamine 
• 115210-54-3 2-methyl-5-nitroindoline 

Relevant articles and documents

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing studies we have discovered that a strategically placed chiral center of appropriate absolute configuration improves the antibacterial activity of indolinyl oxazolidinone analogues (gram-positive MIC's0.5 μg/mL for the most potent congeners). The design, synthesis, antibacterial activity and pharmacokinetic profile of a selected series of α-methylated indoline derivatives and a related set of tetrahydroquinolyl and dihydrobenzoxazinyl analogues are discussed.