312310-50-2Relevant articles and documents
1,4-Asymmetric reduction of γ-keto sulfoxides bearing the 2,4,6-triisopropylphenyl group
Nakamura, Shuichi,Kuroyanagi, Masayuki,Watanabe, Yoshihiko,Toru, Takeshi
, p. 3143 - 3148 (2007/10/03)
Reduction of γ-keto sulfoxides bearing the 2,4,6-triisopropylphenyl group with DIBAL gives γ-hydroxy sulfoxides with high stereoselectivity in the ratio 95:5. In comparison with the lower stereoselectivities obtained in the reaction of γ-keto sulfoxides bearing p-tolyl or 2,4,6-trimethylphenyl groups, the sterically bulky (2,4,6-triisopropylphenyl)-sulfinyl group is extremely efficient in effecting high 1,4-remote asymmetric induction. The Royal Society of Chemistry 2000.