3124-37-6

Basic information

• Product Name: 2-(trimethylsilyl)ethyl carbamate
• CAS NO: 3124-37-6
• Molecular Formula: C₆H₁₅NO₂Si
• Molecular Weight: 161.2743
• Mol File: 3124-37-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 232.8°C at 760 mmHg
• Flash Point: 94.6°C
• Density: 0.946g/cm³
• Vapor Pressure: 0.0579mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 2-(trimethylsilyl)ethyl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trimethylsilyl)ethyl carbamate(3124-37-6)
• EPA Substance Registry System: 2-(trimethylsilyl)ethyl carbamate(3124-37-6)

Safety Data

• Hazardous Substances Data: 3124-37-6(Hazardous Substances Data)

Usage

Derived from

carbamic acid

Formation

Reacts with phosgene or diphosgene

Uses

protecting group for amines in organic synthesis, reagent in the synthesis of other organic compounds, and in the pharmaceutical industry

Properties

easily removed under mild conditions, versatile compound with a range of applications in chemical synthesis.

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 57-13-6 urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1885-14-9 phenyl chloroformate 
• 917-61-3 sodium isocyanate 

Downstream Products

• 872864-53-4 (R)-2-(trimethylsilyl)ethyl 2-hydroxy-4-(4-nitrophenoxy)-butylcarbamate 
• 872864-63-6 (R)-2-(trimethylsilyl)ethyl 1-hydroxy-4-(4-nitrophenoxy)-butan-2-ylcarbamate 
• 1115614-39-5 C₁₈H₃₀N₂O₆Si 
• 1115614-31-7 (R)-2-(trimethylsilyl)ethyl 4-(2,6-dimethyl-4-nitrophenoxy)-2-hydroxybutylcarbamate 
• 1115614-48-6 2-(trimethylsilyl)ethyl (2S,3S)-3-hydroxy-5-(4-nitrophenoxy)pentan-2-ylcarbamate 
• 1115614-47-5 2-(trimethylsilyl)ethyl (2R,3R)-3-hydroxy-5-(4-nitrophenoxy)pentan-2-ylcarbamate 
• 1115614-52-2 2-(trimethylsilyl)ethyl (3S,4S)-4-hydroxy-1-(4-nitrophenoxy)pentan-3-ylcarbamate 

Relevant articles and documents

PYRIDO OXAZINE AMINO DERIVATIVES AS ALK5 INHIBITORS

The present invention relates to a compound of general formula (I) inhibiting the growth factor receptor transforming β (TGF-β) type I (ALK5), methods for preparing these compounds, pharmaceutical compositions containing them and their therapeutic use. The compounds according to the invention may be useful in the treatment of diseases or conditions associated with the disruption of the ALK5 signaling pathway in a mammal.

Iron-catalyzed reaction of urea with alcohols and amines: A safe alternative for the synthesis of primary carbamates

A general study of the iron-catalyzed reaction of urea with nucleophiles is here presented. The carbamoylation of alcohols allows for the synthesis of N-unsubstituted (primary) carbamates, including present drugs (Felbamate and Meprobamat, without the necessity to apply phosgene and related derivatives. Using amines as nucleophiles gave rise to the respective mono-and disubstituted ureas via selective transamidation reaction. These atom-economical transformations provide a direct and selective access to valuable compounds from cheap and readily available urea using a simple Lewis-acidic iron(Icatalyst.

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.