312488-75-8Relevant academic research and scientific papers
Oxygenated chalcones and bischalcones as potential antimalarial agents
Ram, Vishnu J.,Saxena, Abhishek S.,Srivastava, Shalini,Chandra, Subhash
, p. 2159 - 2161 (2000)
Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity at 100 mg/kg dose against sensitive strain. (C) 2000 Elsevier Science Ltd.
Oxygenated chalcones and bischalcones as a new class of inhibitors of DNA topoisomerase II of malarial parasites
Srivastava, Shalini,Joshi, Shweta,Singh, Alok R.,Yadav, Sarika,Saxena,Ram,Chandra, Subhash,Saxena
, p. 234 - 244 (2008/12/22)
The DNA topoisomerase (topo) II of chloroquine-sensitive and chloroquine-resistant strains of the rodent malaria parasite P. berghei were utilized as a target for testing of antimalarial compounds. Compounds belonging to the bischalcone and chalcone serie
