312494-91-0Relevant academic research and scientific papers
Investigations of the reaction mechanism concerning the formation of a 9-hydroxy-β-carboline-4-carboxylic acid from the nifedipine analogous biscyanoethyl ester
Gorlitzer,Baltrusch
, p. 747 - 750 (2007/10/03)
The 3-tert-butyl-5-methyl-1,4-dihydropyridine(DHP)-dicarboxylate 5 reacts with trifluoroacetic acid (TFA) by elimination of the tert-butylester group yielding the 1,4-DHP 6. Irradiation of 6 by UV-A-light affords the corresponding pyridine 7 and the cyclic hydroxamic acid 10. The 2-cyanoethyl-1,4-DHP-carboxylate 13, obtained from the 3-tert-butyl-5-(2-cyano-ethyl)-1,4-DHP-dicarboxylate 12 by treating with TFA, reacts with sodium hydroxide solution to give the title compound 3.
