31251-28-2

Usage

Uses

Used in Pharmaceutical Industry:
3-piperidin-3-ylpyridine is used as a key building block for the synthesis of various pharmaceuticals due to its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-piperidin-3-ylpyridine serves as a fundamental component in the creation of agrochemicals, potentially enhancing crop protection and management strategies.
Used for Antiviral Applications:
3-piperidin-3-ylpyridine is utilized as an antiviral agent, leveraging its biological activities to combat viral infections, offering a promising avenue for the development of antiviral medications.
Used for Antimalarial Applications:
3-piperidin-3-ylpyridine is also considered for its antimalarial properties, making it a candidate for the synthesis of drugs aimed at treating malaria.
Used as a Corrosion Inhibitor:
3-piperidin-3-ylpyridine has been studied for its potential as a corrosion inhibitor, suggesting its use in industrial applications to protect materials from degradation.
Used as a Ligand for Metal Complexes:
Furthermore, 3-piperidin-3-ylpyridine is explored as a ligand for the formation of metal complexes, which can have applications in catalysis, materials science, and other specialized fields.

Upstream product

• 581-46-4 3,3'-bipyridine 
• 33349-46-1 3-(3'-pyridinyl)pyridine N-oxide 
• 626-55-1 3-Bromopyridine 
• 149108-74-7 5-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction

Background and Purpose: Beta cell apoptosis is a major feature of type 1 diabetes, and pro-inflammatory cytokines are key drivers of the deterioration of beta cell mass through induction of apoptosis. Mitochondrial stress plays a critical role in mediating apoptosis by releasing cytochrome C into the cytoplasm, directly activating caspase-9 and its downstream signalling cascade. We aimed to identify new compounds that protect beta cells from cytokine-induced activation of the intrinsic (mitochondrial) pathway of apoptosis. Experimental Approach: Diabetogenic media, composed of IL-1β, IFN-γ and high glucose, were used to induce mitochondrial stress in rat insulin-producing INS1E cells, and a high-content image-based screen of small molecule modulators of Casp9 pathway was performed. Key Results: A novel small molecule, ATV399, was identified from a high-content image-based screen for compounds that inhibit cleaved caspase-9 activation and subsequent beta cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose, which together mimic the pathogenic diabetic milieu. Through medicinal chemistry optimization, potency was markedly improved (6–30 fold), with reduced inhibitory effects on CYP3A4. Improved analogues, such as CAT639, improved beta cell viability and insulin secretion in cytokine-treated rat insulin-producing INS1E cells and primary dispersed islet cells. Mechanistically, CAT639 reduced the production of NO by allosterically inhibiting dimerization of inducible NOS (iNOS) without affecting its mRNA levels. Conclusion and Implications: Taken together, these studies demonstrate a successful phenotypic screening campaign resulting in identification of an inhibitor of iNOS dimerization that protects beta cell viability and function through modulation of mitochondrial stress induced by cytokines.

PYRROLOTRIAZINE KINASE INHIBITORS

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of such as TrkA, TrkB, TrkC, Jak2, Jak3 and CK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.

From bipyridines to tobacco alkaloids and related compounds

Starting from structural considerations which led to the hypothesis that a chemical relationship could exist between two families of natural compounds (mainly pyridinic and pyrrolidinic alkaloids), experiments were carried out in order to establish a correlation route between the two studied classes. Of special interest was the central position of nicotine in these studies, and the main part of this work was devoted to the synthesis of nicotine starting from bipyridines. It was thus necessary to determine the conditions for selective reactions on one aromatic ring of bipyridines (N-methylation, N-oxidation and reduction of the heterocycle). Ring contraction procedure allowed us to obtain nicotine from the parent compound (3,3′-bipyridine). Complementary studies yielded various isomers of piperidinylpyridines (hexahydro derivatives of bipyridines) in a regiochemically controlled manner by means of original methods. Elsevier,.

Reduction Regiospecifique des Bipyridines

A method for the specific reduction of bipyridines through the use of the N-oxo derivatives is described.