312689-77-3

Upstream product

• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 312689-59-1 (S)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione 
• 312689-81-9 (S)-1-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-(4-hydroxy-benzyl)-4-(3aR,7aS)-octahydro-isoindol-2-yl-butane-1,4-dione 
• 312689-80-8 (S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid 

Relevant academic research and scientific papers

First stereoselective synthesis of a Tyr-Tyr E-alkene isostere

A stereoselective synthesis of a tyrosine-tyrosine E-alkene isostere is described. Starting from N-Fmoc-O-(tert-butyl)tyrosine as N-terminal component, the E double bond was generated by a Julia-Kocieński olefination. An enantioselective aldol reaction wa

Synthesis of two dipeptide isosteres containing di- and trisubstituted E-configured double bonds

The stereoselective syntheses of a Tyr-Tyr and a Pro-Pro E-alkene isostere are described. While the Tyr-Tyr isostere was synthesized following a convergent olefination strategy, the trisubstituted E-configured double bond of the Pro-Pro isostere was generated by an Ireland-Claisen rearrangement. The configuration of all key intermediates containing new stereocenters was determined by X-ray crystallography. Georg Thieme Verlag Stuttgart.