31271-90-6

Basic information

• Product Name: N-(P-TOLUENESULFONYL)INDOLE
• Synonyms: 1-tosylindole;N-Tosylindole;N-Ts-indole;1-[(4-Methylphenyl)sulfonyl]-1H-indole
• CAS NO: 31271-90-6
• Molecular Formula: C₁₅H₁₃NO₂S
• Molecular Weight: 271.07
• Mol File: 31271-90-6.mol
• Article Data: 123

Chemical Properties

• Melting Point: 84-86°C
• Boiling Point: 458.269 °C at 760 mmHg
• Flash Point: 230.953 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: N-(P-TOLUENESULFONYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(P-TOLUENESULFONYL)INDOLE(31271-90-6)
• EPA Substance Registry System: N-(P-TOLUENESULFONYL)INDOLE(31271-90-6)

Safety Data

• Hazardous Substances Data: 31271-90-6(Hazardous Substances Data)

Usage

Uses

1-(p-Toluenesulfonyl)indole, is synthesized and used as a stable equivalent of 4-mercaptoindoles, also used in medicinal field for making drug and tablets.

InChI:InChI=1/C15H13NO2S/c1-12-6-8-14(9-7-12)19(17,18)16-11-10-13-4-2-3-5-15(13)16/h2-11H,1H3

Upstream product

• 120-72-9 indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 30765-95-8 N-p-toluenesulfonyl-2-vinylaniline 
• 136787-89-8 N-tosyl-2-(1-isopropylthio-2-methoxyethyl)anilide 
• 136787-90-1 N-tosyl-2-<1-acetoxy-2-(isopropylthio)ethyl>anilide 
• 136787-88-7 N-tosyl-2-<2-acetoxy-1-(isopropylthio)ethyl>anilide 
• 67-56-1 methanol 
• 512779-63-4 5-benzenesulfinyl-1-(toluene-4-sulfonyl)-1H-indole 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 941-55-9 4-toluenesulfonyl azide 
• 931-49-7 1-ethenylcyclohexene 
• 28075-50-5 cyclohex-1-en-1-yl trifluoromethane sulfonate 

Downstream Products

• 87066-80-6 cis-3-hydroxy-2-methoxy-1-tosylindoline 
• 87066-80-6 trans-3-hydroxy-2-methoxy-1-tosylindoline 
• 74786-92-8 Phenyl-acetic acid (2R,3S)-3-phenylacetoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-2-yl ester 
• 125031-65-4 2-(3,6-Dimethyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 125031-61-0 3-(3,6-Dimethyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 114906-90-0 (E)-1-(1-tosyl-1H-indol-3-yl)but-2-en-1-one 
• 125031-67-6 2-(3,6-Diisopropyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 125031-63-2 3-(3,6-Diisopropyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 90481-77-9 3-bromo-1-(4-methylbenzenesulfonyl)-1H-indole 
• 74786-90-6 trans-ethanoic acid [2-acetoxy-1-(4-toluenesulfonyl)-2,3-dihydro-1H-indol-3-yl]diester 
• 91476-96-9 3-Phenyl-8-(toluene-4-sulfonyl)-8,8a-dihydro-3aH-isoxazolo[5,4-b]indole 
• 125031-62-1 3-(3,6-Diethyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 125031-66-5 2-(3,6-Diethyl-pyrazin-2-yl)-1-(toluene-4-sulfonyl)-1H-indole 
• 91476-97-0 8-(Toluene-4-sulfonyl)-3-(2,4,6-trimethyl-phenyl)-8,8a-dihydro-3aH-isoxazolo[5,4-b]indole 

Relevant articles and documents

Electrophilic fluorination in the synthesis of new fluoroindoles

Fluorination of trialkylstannylindoles with caesium fluoroxysulfate on Selectfluor(TM) was investigated for the synthesis of inter-alia 2- and 3- fluoroindoles. Caesium fluoroxysulfate gave good yields of these potentially useful intermediates. Selectfluo

Silaphenylmercuric triflate catalyzed reactions: Synthesis of a solid-supported mercuric salt catalyst

Let it flow, let it flow: A procedure to generate the first solid-supported mercuric salt, silaphenylmercuric triflate, is described. Silaphenylmercuric triflate showed remarkable catalytic activity for an indole synthesis, furanoyne cyclization, arylyne

A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N-Arylynamides

Treatment of ynamides with a catalytic amount of TpRuCl(PPh3)2 resulted in the construction of indole scaffolds known as privileged structure motifs. This reaction involved a cascade of 1,2-rearrangement and cyclization carrying out C?C bond formation via a ruthenium vinylidene intermediate, as revealed by a deuterium-labeling experiments. Furthermore, the transformation of multi-functionalized ynamide, derived from a practical drug molecule, showed a high functional group tolerance of this reaction. (Figure presented.).

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I