31272-04-5

Usage

Uses

Used in Food and Beverage Industry:
1-METHYL-3-N-PROPYL-2-PYRAZOLIN-5-ONE is used as a flavor enhancer for its ability to impart a savory or umami taste to foods and beverages, enhancing the overall flavor profile and consumer experience.
Used in Pharmaceutical Industry:
1-METHYL-3-N-PROPYL-2-PYRAZOLIN-5-ONE is used as a flavor enhancer in pharmaceutical products to improve the taste and palatability of medications, making them more acceptable for consumption.
Used in Cosmetic Industry:
1-METHYL-3-N-PROPYL-2-PYRAZOLIN-5-ONE is used as a flavor enhancer in cosmetic products, particularly those that may be ingested or come into contact with the mouth, to provide a more pleasant taste or scent.

InChI:InChI=1/C7H12N2O/c1-3-4-6-5-7(10)9(2)8-6/h3-5H2,1-2H3

Upstream product

• 3249-68-1 ethyl butyroyl acetate 
• 60-34-4 methylhydrazine 

Downstream Products

• 1210911-82-2 C₁₈H₂₆N₄O₂ 

Relevant academic research and scientific papers

Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors

AKR1C3 is a promising therapeutic target for castration-resistant prostate cancer. Herein, an evaluation of in-house library discovered substituted pyranopyrazole as a novel scaffold for AKR1C3 inhibitors. Preliminary SAR exploration identified its derivative 19d as the most promising compound with an IC50 of 0.160 μM among the 23 synthesized molecules. Crystal structure studies revealed that the binding mode of the pyranopyrazole scaffold is different from the current inhibitors. Hydroxyl, methoxy and nitro group at the C4-phenyl substituent together anchor the inhibitor to the oxyanion site, while the core of the scaffold dramatically enlarges but partially occupies the SP pockets with abundant hydrogen bond interactions. Strikingly, the inhibitor undergoes a conformational change to fit AKR1C3 and its homologous protein AKR1C1. Our results suggested that conformational changes of the receptor and the inhibitor should both be considered during the rational design of selective AKR1C3 inhibitors. Detailed binding features obtained from molecular dynamics simulations helped to finally elucidate the molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as AKR1C3 inhibitors, which would facilitate the future rational inhibitor design and structural optimization.

POLYCYCLIC DERIVATIVES TARGETING RAL GTPASES AND THEIR THERAPEUTICAL APPLICATIONS

Contemplated compounds, compositions and methods are directed to Ral GTPase inhibitors with improved activity.

Synthesis of some novel pyrazolopyridooxazine, pyrazoloquinolizines, pyrazoloindolizine and pyrazolopyranopyrimidinone derivatives

Different pyrazolone derivatives were prepared as starting materials for the synthesis of pyrazolopyridooxazine, pyrazoloquinolizines, pyrazoloindolizine, 1,4-oxazinopyrazolines and pyrazolopyranopyrimidinone derivatives via reactions with different reagents applying the one pot multicomponent reaction using microwave and ultrasound irradiation in some cases.

ORGANIC DYE COMPOUND AND HIGH DENSITY OPTICAL RECORDING MEDIUM INCLUDING THE SAME

A recording layer including a novel organic dye compound (I) for a high density optical recording medium is provided. The organic dye compound (I) has the following general chemical structural formula: wherein R1, R2, R3, R4 and R5 each independently represent H, alkyl, halide, nitro, benzyl group or substituted benzyl group. The organic dye compound (I) exhibits a maximum absorbance at a wavelength range of 400-550 nm.