31272-21-6

Basic information

• Product Name: (5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone
• Synonyms: (5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone
• CAS NO: 31272-21-6
• Molecular Formula: C₁₂H₁₂FN₃O
• Molecular Weight: 233.27
• Mol File: 31272-21-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 249°C (rough estimate)
• Flash Point: 210°C
• Appearance: /
• Density: 1.2438 (estimate)
• Vapor Pressure: 2.19E-07mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: (5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone(31272-21-6)
• EPA Substance Registry System: (5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone(31272-21-6)

Safety Data

• Hazardous Substances Data: 31272-21-6(Hazardous Substances Data)

Usage

General Description

The chemical "(5-amino-1,3-dimethylpyrazol-4-yl)-(2-fluorophenyl)methanone" is a compound with the molecular formula C12H12N4OF. It is synthesized by combining 5-amino-1,3-dimethylpyrazole-4-carbaldehyde and 2-fluorobenzoyl chloride. This chemical compound is commonly used in pharmaceutical research and drug development due to its potential as an anti-inflammatory and analgesic agent. It is also being studied for its potential applications in the treatment of neurodegenerative diseases and cancer. The compound exhibits a wide range of biological activities and has shown promise in various preclinical studies. Further research and clinical trials are needed to explore and harness the full potential of this chemical for medical and therapeutic purposes.

InChI:InChI=1/C12H12FN3O/c1-7-10(12(14)16(2)15-7)11(17)8-5-3-4-6-9(8)13/h3-6H,14H2,1-2H3

Upstream product

• 85723-94-0 N-<4-(2-Fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl>benzamide 
• 54384-73-5 N-(1,3-Dimethyl-1H-pyrazol-5-yl)benzamide 
• 85723-93-9 N-(4-Bromo-1,3-dimethyl-1H-pyrazol-5-yl)benzamide 
• 394-35-4 methyl 2-fluorobenzoate 
• 103068-62-8 5-<<(dimethylamino)methylene>amino>-α-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-methanol 
• 103068-65-1 2-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-isoindole-1,3(2H)-dione 
• 103068-61-7 5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde 
• 1072-85-1 o-fluorobromobenzene 
• 31272-25-0 [5-(2-fluoro-benzoylamino)-1,3-dimethyl-1H-pyrazol-4-yl]-(2-fluoro-phenyl)-methanone 
• 103068-66-2 2-<4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl>-1H-isoindole-1,3(2H)-dione 
• 103068-63-9 <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone 

Downstream Products

• 103068-71-9 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-(4-phenyl-piperidin-1-yl)-acetamide 
• 85723-38-2 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-{methyl-[3-(2-methyl-piperidin-1-yl)-propyl]-amino}-acetamide 
• 85723-32-6 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-[3-(4-methyl-piperidin-1-yl)-propylamino]-acetamide 
• 85723-34-8 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-[3-(3-methyl-piperidin-1-yl)-propylamino]-acetamide 
• 85723-20-2 N-[4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl]-2-{[3-(2-methyl-1-piperidinyl)propyl]amino}acetamide 
• 85723-44-0 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-(3-piperidin-1-yl-propylamino)-acetamide 
• 85723-48-4 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-(2-piperidin-1-yl-ethylamino)-acetamide 
• 103068-88-8 2-(2-Diisopropylamino-ethylamino)-N-[4-(2-fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-acetamide 
• 85723-42-8 2-(3-tert-Butylamino-propylamino)-N-[4-(2-fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-acetamide 
• 85723-22-4 2-(3-Dimethylamino-propylamino)-N-[4-(2-fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-acetamide 
• 85747-92-8 2-(diethylamino)-N-<4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl>acetamide 
• 85723-12-2 N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-(4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)-acetamide 
• 103068-81-1 4-(2-Fluoro-phenyl)-1,3-dimethyl-5-{methyl-[3-(2-methyl-piperidin-1-yl)-propyl]-amino}-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one 
• 103094-26-4 4-(2-Fluoro-phenyl)-1,3-dimethyl-5-[3-(4-methyl-piperidin-1-yl)-propylamino]-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one 

Relevant articles and documents

(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl) methanones. A series of novel potential antipsychotic agents

-

(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants

A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. Pharmacological evaluation of these compounds demonstrated central nervous system depressant activity, potential anticonvulsant properties, and a low order of acute toxicity. In addition, selected compounds showed potential antipsychotic effects. This report focuses on the synthesis and structure-activity relationships of these compounds. (5-Amino-1-ethyl-3-methyl-1H-pyrazol-4-yl)(2-chlorophenyl)methanone was the most active compound against pentylene-tetrazole-induced convulsions. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-chlorophenyl)methanone also has a favorable anticonvulsant depression ratio. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-trifluoromethylphenyl)methanone, (5-amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-thienyl)methanone and (5-amino-3-ethyl-1-methyl-1H-pyrazol-4-yl)phenylmethanone are very potent depressants. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-thienyl)methanone possessed marked central depressant activity without anticonvulsant activity and without impairment of motor functioning. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanone has a behavioral profile suggestive of antipsychotic activity and gave a positive Ames test result.