312728-28-2

Basic information

• Product Name: tert-butyl but-3-enyl(methyl)carbamate
• Synonyms: N-methyl-N-(tert-butoxycarbonyl)-3-buten-1-amine;tert-butyl but-3-enyl(methyl)carbamate;tert-butyl but-3-en-1-yl(methyl)carbamate
• CAS NO: 312728-28-2
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.26336
• Mol File: 312728-28-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl but-3-enyl(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl but-3-enyl(methyl)carbamate(312728-28-2)
• EPA Substance Registry System: tert-butyl but-3-enyl(methyl)carbamate(312728-28-2)

Safety Data

• Hazardous Substances Data: 312728-28-2(Hazardous Substances Data)

Upstream product

• 7541-17-5 tert-butyl N,N-dimethylcarbamate 
• 19206-69-0 allyl diphenyl phosphate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 38369-88-9 N-methyl-3-butenylamine 
• 74-88-4 methyl iodide 
• 156731-40-7 tert-butyl N-but-3-enylcarbamate 

Downstream Products

• 189274-78-0 TC-2559 

Relevant articles and documents

Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions

Investigation of TRPV4 as a potential target for the treatment of pulmonary edema associated with heart failure generated a novel series of acyclic amine inhibitors displaying exceptional potency and PK properties. The series arose through a scaffold hopp

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.

Regio- and enantioselective control in the reactions of α-(N-Carbamoyl)alkylcuprates with allylic phosphates

α-(N-Carbamoyl)alkylcuprates (RCuCNLi or R2CuLi) react with allylic phosphates to afford homoallylic amines in good chemical yields. Regioselectivity is governed by steric factors in both the cuprate reagent and phosphate substrate and systems can be designed to give either the S N2′ or SN2 substitution product cleanly. Excellent enantioselectivities can be achieved with either a scalemic α-di[(N- carbamoyl)-alkyl]cuprate and an achiral phosphate or with a scalemic allylic phosphate and an achiral cuprate reagent.