312746-74-0

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indazole-7-carboxamide(9CI) is used as a drug candidate for its potential anti-inflammatory and analgesic properties. It is being studied for its ability to alleviate inflammation and pain, which could be beneficial in the treatment of various conditions that involve these symptoms.
Used in Drug Development and Discovery:
Due to its promising pharmacological profile, 1H-Indazole-7-carboxamide(9CI) is utilized in the drug development and discovery process. Researchers are interested in its potential to contribute to the creation of new medications that could address unmet medical needs or improve upon existing treatments.

InChI:InChI=1/C8H7N3O/c9-8(12)6-3-1-2-5-4-10-11-7(5)6/h1-4H,(H2,9,12)(H,10,11)

Upstream product

• 677304-69-7 1H-indazole-7-carboxylic acid 

Downstream Products

• 952475-01-3 2-(4-formylphenyl)-2H-indazole-7-carboxamide 
• 952479-68-4 2-(4-nitrophenyl)-2H-indazole-7-carboxamide 

Relevant academic research and scientific papers

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.