312774-38-2Relevant academic research and scientific papers
Synthesis of α-N-ethylamino acids and their derivatives
Schedel, Hartmut,Burger, Klaus
, p. 1011 - 1018 (2000)
A new synthesis of α-N-ethylamino acids starting from α-amino acids using hexafluoroacetone as protecting and activating agent is described. The hexafluoroacetone-protected N-ethylamino acid derivatives obtained are activated lactons. Therefore, they can be directly transformed without the need of an additional activation step with various nucleophiles into the corresponding carboxylic acid derivatives.
