31281-82-0

Upstream product

• 133462-95-0 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester di-tert-butyl ester 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 104655-85-8 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropyl-H-phosphonamidate 

Downstream Products

• 76759-76-7 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-bis(2-cyanoethyl)phosphate 

Relevant academic research and scientific papers

A new method for the phosphorylation of nucleosides

A new phosphorylating reagent, 2-O-(4,4'-dimethoxytrityl)ethylsulfonylethan-2'-yl-phosphate (1), was developed for the phosphorylation of primary and secondary alcohols of nucleosides. In the many examples studied, yields in the phosphorylation step were excellent (~80 to 95%). There is potential for wide applicability of this procedure, not only in nucleoside and nucleotide chemistry, but also in the phosphorylation of biomolecules such as carbohydrates and amino acids. (C) 2000 Elsevier Science Ltd.

A facile method for the oxidation of nucleoside H-phosphonates to phosphates with bis(trimethylsilyl) peroxide

We have developed a convenient method for achieving the oxidation of nucleoside H-phosphonic acid monoesters and diesters with bis(trimethylsilyl) peroxide and N,O-bis(trimethylsilyl)acetamide in the presence of trimethylsilyl triflate as a catalyst.

A convenient method for removal of the t-butyl group from nucleoside bis(t-butyl) phosphates under non-acidic conditions

A new method for selective removal of the t-butyl group from 3′ - bis(t-butyl) phosphate esters of 5′-0-(4,4′-dimethoxytrityl)deoxyribo-nucleosides was developed by use of Me3SiCl and Et3N. Several unexpected properties of the t-buty

A NEW AND VERSATILE APPROACH TO THE PREPARATION OF VALUABLE DEOXYNUCLEOSIDE 3'-PHOSPHITE INTERMEDIATES

The easily accessible and crystalline monofunctional phosphitylating reagent bis-(diisopropylamino)chlorophosphine has been used for the synthesis of phosphoramidites and H-phosphonates of d-nucleosides and, also, the formation of 3'-5'-internucleotidic phosphonate bonds.

Chemical Synthesis of 5'-Phosphorylated DNA Fragments and Their Constituents

Phosphoryl tris-triazole has been applied to the synthesis of DNA fragments and their constituents bearing 5'-phosphomonoester function and to the preparation of deoxynucleoside 5'- or 3'-diphosphates.