3129-16-6

Upstream product

• 109-77-3 malononitrile 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 1207341-19-2 methyl 4-{(1E)-4,4-dicyano-3-[4-(dimethylamino)phenyl]buta-1,3-dien-1-yl}benzoate 
• 1379609-88-7 methyl 4-(2,2-dicyano-1-methoxy-3,3-dimethylpent-4-en-1-yl)benzoate 

Relevant academic research and scientific papers

Controllable one-pot synthesis for scaffold diversity: Via visible-light photoredox-catalyzed Giese reaction and further transformation

This study presents a controllable one-pot synthesis for constructing valuable scaffolds (alcohols, 2,3-dihydrofurans, α-cyano-γ-butyrolactones, and γ-butyrolactones) via a visible-light photoredox-catalyzed Giese reaction and further transformation. This

Visible-Light Photoredox-Catalyzed α-Regioselective Conjugate Addition of Allyl Groups to Activated Alkenes

The α-regioselective conjugate addition of allyl groups to activated alkenes is a poorly explored area of research. Herein, we report an α-adduct and (E)-isomer selective conjugate addition of allylsilanes to activated alkenes by visible-light photoredox catalysis. The reaction involves allylic radicals that can be generated from allylsilanes through a photoinduced single-electron transfer mechanism. (Figure presented.).

Three-Dimensional Co(II)-Metal-Organic Frameworks with Varying Porosities and Open Metal Sites toward Multipurpose Heterogeneous Catalysis under Mild Conditions

In recent years, heterogeneous catalysis has become one of the most active domains in the research of metal-organic frameworks (MOFs). Here, two three-dimensional (3D) Co(II)-MOFs with open metal sites and exposed azo functionality on the MOF backbone hav

New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.

Visible-Light Photoredox-Catalyzed Hydroalkoxymethylation of Activated Alkenes Using α-Silyl Ethers as Alkoxymethyl Radical Equivalents

A new neutral silicon-based traceless activation group (TAG) for visible-light photoredox-catalyzed hydroalkoxymethylation of alkenes is presented. This reaction involves in-situ-generated alkoxymethyl radical via single electron oxidation (SET) of α-TMS-substituted ethers, followed by subsequent conjugate addition to activated alkenes. Various functional groups were tolerated both under mild metal and metal-free conditions to provide good to excellent yields. Furthermore, the addition products were transformed to valuable synthetic building blocks, such as carboxylic acids,-butyrolactones, and complex aryl alkyl ethers.

An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines

A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mil

Fe-catalyzed multicomponent reactions: The regioselective alkoxy allylation of activated olefins and its application in sequential Fe catalysis

We present herein a versatile and broadly applicable Fe-catalyzed regioselective alkoxy allylation of activated double bonds. Substituted allylic carbonates are converted into the corresponding σ-enyl Fe complexes by reaction with Bu4N[Fe(CO)s

The use of electroosmotic flow as a pumping mechanism for semi-preparative scale continuous flow synthesis

By employing a series of reactions we demonstrate the use of electroosmotic flow as a continuous pumping mechanism suitable for semi-preparative scale synthesis, affording an array of small organic compounds, of analytical purity, with yields ranging from 0.57-1.71 g h-1. The Royal Society of Chemistry.