312904-51-1

Basic information

• Product Name: 2-Pyridinemethanamine,3-fluoro-(9CI)
• Synonyms: 2-Pyridinemethanamine,3-fluoro-(9CI);2-(AMinoMethyl)-3-fluoropyridine;[(3-Fluoropyridin-2-yl)methyl]amine;C-(3-Fluoro-pyridin-2-yl)-methylamine
• CAS NO: 312904-51-1
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.133
• Product Categories: PYRIDINE
• Mol File: 312904-51-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 176.0±25.0℃ (760 Torr)
• Flash Point: 60.2±23.2℃
• Appearance: /
• Density: 1.180±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Pyridinemethanamine,3-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanamine,3-fluoro-(9CI)(312904-51-1)
• EPA Substance Registry System: 2-Pyridinemethanamine,3-fluoro-(9CI)(312904-51-1)

Safety Data

• Hazardous Substances Data: 312904-51-1(Hazardous Substances Data)

Usage

General Description

2-Pyridinemethanamine, 3-fluoro- (9CI) is a chemical compound that belongs to the class of pyridine derivatives. It is also known as 3-fluoropyridin-2-ylmethanamine. This chemical is used in the synthesis of pharmaceutical compounds, agrochemicals, and other organic compounds. It has potential applications in the field of medicinal chemistry and drug development due to its unique structural properties. 2-Pyridinemethanamine, 3-fluoro- (9CI) is a valuable building block in organic synthesis and has the potential to be used in the development of novel compounds with biological activities.

InChI:InChI=1/C6H7FN2/c7-5-2-1-3-9-6(5)4-8/h1-3H,4,8H2

Upstream product

• 31224-43-8 3-fluoropyridine-2-carbaldehyde 
• 97509-75-6 3-fluoropicolinonitrile 
• 1260903-05-6 2-aminomethyl-3-fluoropyridine dihydrochloride 

Downstream Products

• 1431656-22-2 8-fluoro-3-phenylimidazo[1,5-a]pyridine 
• 1431656-33-5 N-[(3-fluoropyridin-2-yl)methyl]benzamide 
• 1036862-56-2 C₂₂H₁₇F₄N₅O 

Relevant articles and documents

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.