312912-68-8Relevant academic research and scientific papers
Excitatory amino acid receptor modulators
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, (2008/06/13)
Compounds of formula (I) in which R1is halo-C1-10alkyl; halo-C2-10alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8and R9are each selected independently from C1-4alkyl, aryl and aryl-C1-4alkyl; R4is selected from C1-4alkyl, aryl, aryl-C1-4alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.
