312929-60-5Relevant academic research and scientific papers
Synthesis and: In vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2
Bozorov, Khurshed,Zhao, Jiang Yu,Nie, Li Fei,Ma, Hai-Rong,Bobakulov, Khayrulla,Hu, Rui,Rustamova, Nigora,Huang, Guozheng,Efferth, Thomas,Aisa, Haji A.
, p. 31417 - 31427 (2017)
On the basis of high-throughput screening, fragment-based drug discovery, structure-activity relationships and building block analysis methods, herein we report the synthesis and biological evaluation of a novel series of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives. All of the prepared Schiff bases (with mono-, di- and poly-substituents at the aromatic portion), mono- and bis-amides of diethyl 2,5-diaminothiophene-3,4-dicarboxylate, were evaluated against various human cancer and non-cancerous (only for active compounds) cell lines, as well as influenza A (subtypes FM/1/47/H1N1, hanfang/359/95/H3N2) and B (subtype jifang/13/97) viruses. The obtained results suggest that some selected compounds revealed promising antitumor and antiviral activities and may serve as lead compounds for further drug discovery and development.
