312934-48-8

Basic information

• Product Name: 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine
• Synonyms: 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine
• CAS NO: 312934-48-8
• Molecular Weight: 712.581
• Mol File: 312934-48-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine(312934-48-8)
• EPA Substance Registry System: 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine(312934-48-8)

Safety Data

• Hazardous Substances Data: 312934-48-8(Hazardous Substances Data)

Upstream product

• 318246-79-6 5'-O-(tert-butyldiphenylsilyl)-3'-O-(3-tert-butylphenoxythio-carbonyl)-2'-O-(2-methoxyethyl)-5-methyluridine 
• 337980-11-7 5'-O-(tert-butyldiphenylsilyl)-3'-deoxy-2'-O-(2-methoxyethyl)-3'-C-(2-phenylethenyl)-5-methyluridine 
• 318246-92-3 5'-O-(tert-butydiphenylsilyl)-3'-deoxy-3'-C-(hydroxymethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 
• 318246-74-1 5'-O-t-Butyldiphenylsilyl-2'-O-(methoxyethyl)-5-methyluridine 
• 312934-29-5 5'-O-(tert-butydiphenylsilyl)-3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 312934-35-3 3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5-methyluridine 

Downstream Products

• 318247-02-8 3'-deoxy-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-3'-C-methyl-5-methyluridine 

Relevant articles and documents

NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYERMASE

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Synthesis of novel 3'-methylene H-phosphonate thymidines

The synthesis of novel 5'-DMT- and 5'-MMT-protected 3'-methylene H-phosphonate thymidines 1-6, having methoxy, fluoro, hydrogen, and methoxyethoxy substituents at the 2'-position is reported. (C) 2000 Elsevier Science Ltd.