312962-23-5

Upstream product

• 312962-21-3 2-allyl-6-hydroxy-benzoic acid (1R,3S,4R)-1-[2-(4-methoxy-benzyloxy)-ethyl]-3-methoxymethoxy-4,7-dimethyl-oct-6-enyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 312962-11-1 (4S,5R)-3-((2R)-2,5-dimethyl-hex-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 312962-20-2 (3S,5S,6R)-1-(4-methoxy-benzyloxy)-5-methoxymethoxy-6,9-dimethyl-dec-8-en-3-ol 
• 312962-18-8 (3R,5S,6R)-3-hydroxy-5-methoxymethoxy-6,9-dimethyl-dec-8-enoic acid tert-butyl ester 
• 312962-17-7 (5S,6R)-5-methoxymethoxy-6,9-dimethyl-3-oxo-dec-8-enoic acid tert-butyl ester 
• 312962-19-9 (3S,5S,6R)-5-methoxymethoxy-6,9-dimethyl-dec-8-ene-1,3-diol 
• 312962-16-6 (3S,4R)-3-methoxymethoxy-4,7-dimethyl-oct-6-enoic acid methyl ester 
• 312962-10-0 2-allyl-6-hydroxy-benzoic acid 
• 312962-15-5 (3S,4R)-3-hydroxy-4,7-dimethyl-oct-6-enoic acid methyl ester 
• 312962-14-4 (4R)-4,7-dimethyl-3-oxo-oct-6-enoic acid methyl ester 
• 312962-12-2 (2R)-2,5-dimethyl-hex-4-enoic acid 
• 312962-13-3 (2R)-2,5-dimethyl-hex-4-enoyl chloride 
• 204846-40-2 2,2-dimethyl-5-(2-propenyl)-4H-1,3-benzodioxin-4-one 

Downstream Products

• 312962-27-9 (7R,9S,10R)-4-methoxy-7-[2-(4-methoxy-benzyloxy)-ethyl]-9-methoxymethoxy-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one 

Relevant academic research and scientific papers

Asymmetric synthesis of the fully functional macrolide core of salicylihalamide: remote control of olefin geometry during RCM.

A catalysis-based approach to the core region 24 of the antitumor agents salicylihalamides A and B is reported. Key steps are two asymmetric hydrogenations of beta-keto esters 13 and 16 catalyzed by [(R)-BINAP.RuCl(2)](2).NEt(3) and an RCM-based macrocyclization effected by the NHC-containing ruthenium carbene 21. The stereochemical outcome of the latter reaction is controlled by remote substituents on the phenolic OH group of the cyclization precursor 23.