31301-50-5

Basic information

• Product Name: 4-BroMo-3-Methyl-5-phenylisoxazole
• Synonyms: 4-BroMo-3-Methyl-5-phenylisoxazole
• CAS NO: 31301-50-5
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Mol File: 31301-50-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BroMo-3-Methyl-5-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BroMo-3-Methyl-5-phenylisoxazole(31301-50-5)
• EPA Substance Registry System: 4-BroMo-3-Methyl-5-phenylisoxazole(31301-50-5)

Safety Data

• Hazardous Substances Data: 31301-50-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-methyl-5-phenylisoxazole is a chemical compound with the molecular formula C10H8BrNO. It is a derivative of isoxazole and is known for its use in medicinal and pharmaceutical applications. 4-BroMo-3-Methyl-5-phenylisoxazole is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It has also been studied for its potential biological activities, including its role as a potential anti-cancer agent and as a useful scaffold for the development of new drug molecules. Additionally, 4-bromo-3-methyl-5-phenylisoxazole has been investigated for its antimicrobial and antifungal properties, making it a versatile and valuable chemical compound in pharmaceutical and medicinal research.

Upstream product

• 1817-57-8 4-phenyl-3-butyne-2-one 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 79-24-3 Nitroethane 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 75115-15-0 3-bromo-4-phenyl-but-3-en-2-one oxime 

Downstream Products

• 85231-87-4 3-benzoyl-4-methyl-1,2,5-thiadiazole 

Relevant articles and documents

A Novel Approach to Highly Substituted β-Carbolines via Reductive Ring Transformation of 2-Acyl-3-isoxazolylindoles

We have worked out a new approach to 1,3,4-trisubstituted β-carbolines of pharmaceutical interest. As central building blocks we used 2-acylindoles, which are readily available from indole-2-Weinreb amides. Bromination at C-3, followed by Suzuki–Miyaura c

A novel and convenient synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles: useful intermediates for the solid-phase synthesis of 4,5-diarylisoxazoles

A novel synthesis of 5-aryl-4-bromo-3-carboxyisoxazoles employing a [3+2] cycloaddition of a nitrile N-oxide with 2-aryl-1-bromoalkynes as the key step is described. The utility of these 5-aryl-4-bromo-3-carboxyisoxazoles in the solid-phase synthesis of 4,5-diarylisoxazoles is demonstrated.

Halogenation of Vinyl Ketoximes. Synthesis of Isoxazoles and Preparation and Silver Ion-Promoted Reactions of 4-Halo-2-isoxazolines

Reaction of several α,β-unsaturated ketoximes with N-bromosuccinimide (NBS) gave isoxazoles, but yields were lower and the reaction less general than a similar transformation using iodine under basic conditions.With β,β-disubstituted oximes, 4-halo-5,5-disubstituted-2-isoxazolines were obtained using NBS, iodine, or N-chlorosuccinimide.Treatment of the 4-bromoisoxazolines with silver acetate or silver nitrate caused either elimination with rearrangement to give isoxazoles or substitution at C-4, depending upon the nature of the substituents at C-5.