313230-02-3

Upstream product

• 99-81-0 4-Nitrophenacyl bromide 
• 2293-07-4 1-(4-methoxyphenyl)thiourea 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 36070-57-2 3-[1-(4-Methoxy-phenyl)-thioureido]-propionic acid 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel DI- and trisubstituted thiazole derivatives

Novel di- and trisubstituted thiazole derivatives bearing heterocyclic, aromatic, chalcone, and carboxyalkyl-heterocyclic moieties were synthesized. Compounds possessing significant antibacterial activity, comparable to that of commercial antibacterial agent ampicillin, against Rhizobium radiobacter, Xanthomonas campestris, and Escherichia coli were identified. Some of the synthesized compounds exhibited a very high antioxidant activity.

Design, synthesis and biological evaluation of novel N,4-diphenylthiazol-2-amine derivatives

Novel N,4-diphenylthiazol-2-amine derivatives were designed and synthesized employing Hantzsch method. The three-step reaction involved in the synthesis occurred at a faster rate with excellent yields in eco-friendly conditions. The synthesized derivatives were characterized by spectral techniques such as 1H NMR, 13C NMR, FT-IR and GCMS. Single-crystal X-ray diffraction studies also confirmed the formation of title compounds. These compounds were evaluated in vitro for their antimicrobial and anti-inflammatory activities. The results demonstrated that most of the tested compounds showed potent antifungal activity. Interestingly, these compounds also exhibited good anti-inflammatory and moderate antibacterial activity towards sensitive as well as resistant bacterial strains. In silico studies depicted their good binding affinity profile against S. aureus (PDB ID: 1AD4) and C. albicans (PDB ID: 1AI9). [Figure not available: see fulltext.].

Effect of substituents on the regioselectivity of the reaction of α-tosyloxyketones with thioureas in acidic medium: Access to 2-aminothiazoles and 2-imino-2,3-dihydrothiazoles

Regioselective condensation of α-tosyloxyacetophenones 1 and N-substituted thioureas 2 in acidic medium to give regioisomers 2-aminothiazoles I and 2-imino-2,3-dihydrothiazoles II is largely influenced by the substituents present on 1 and 2. A mechanism,

Lipase and deep eutectic mixture catalyzed efficient synthesis of thiazoles in water at room temperature

Lipase bio-catalyst or ammonium based deep eutectic mixture efficiently catalyzed aqueous phase synthesis of methyl-thiazole and amino-thiazole derivatives. The simple ammonium deep eutectic catalyst, easily synthesized from choline chloride and urea, is inexpensive, recyclable and bio-degradable, making it suitable for industrial applications. Springer Science+Business Media, LLC 2012.