313231-71-9

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
3-Imidazo[1,2-a]pyridin-2-yl-phenylamine is used as a ligand for various receptors and enzymes due to its biological and pharmacological activities. Its unique structure allows it to interact with specific targets, making it a valuable tool in drug discovery and development.
Used in Medicinal Chemistry:
The presence of the imidazo pyridine ring in the structure of 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine suggests potential applications in the field of medicinal chemistry. Its ability to form stable complexes with biological targets can be utilized to design and synthesize new drugs with improved efficacy and selectivity.
Used in Molecular Biology:
3-Imidazo[1,2-a]pyridin-2-yl-phenylamine may also have potential applications in molecular biology, where it can be used to study the interactions between ligands and their target receptors or enzymes. This can provide valuable insights into the molecular mechanisms of various diseases and help in the development of targeted therapies.
Further research and studies are needed to fully understand the properties and potential uses of 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine, as its complex molecular structure and diverse applications hold great promise in the fields of pharmaceuticals, medicinal chemistry, and molecular biology.

Upstream product

• 504-29-0 2-aminopyridine 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 34658-67-8 2-(3-nitrophenyl)imidazo[1,2-a]pyridine 

Downstream Products

• 537021-04-8 N-acetyl-sulfanilic acid-(3-imidazo[1,2-a]pyridin-2-yl-anilide) 
• 1192928-29-2 N-((3-imidazo[1,2-a]pyridin-2-yl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide 

Relevant academic research and scientific papers

Evaluation of catalytic activity of imidazolo[1,2-a] pyridine derivatives: Oxidation of catechol

A series of heterocyclic compounds possessing imidazolo[1,2-a]pyridine moiety, namely, ethyl 7-methylimidazolo[1,2-a] pyridine-2-carboxylate L1; 2-(3-nitrophenyl)imidazo[1,2-a]pyridine L2; 3-(imidazo[1,2-a]pyridine-2-yl) aniline L3; 2-phenylimidazolo[1,2-

Acylthiourea, acylurea, and acylguanidine derivatives with potent Hedgehog inhibiting activity

The Smoothened (Smo) receptor is the major transducer of the Hedgehog (Hh) signaling pathway. On the basis of the structure of the acylthiourea Smo antagonist (MRT-10), a number of different series of analogous compounds were prepared by ligand-based structural optimization. The acylthioureas, originally identified as actives, were converted into the corresponding acylureas or acylguanidines. In each series, similar structural trends delivered potent compounds with IC50 values in the nanomolar range with respect to the inhibition of the Hh signaling pathway in various cell-based assays and of BODIPY-cyclopamine binding to human Smo. The similarity of their biological activities, in spite of discrete structural differences, may reveal the existence of hydrogen-bonding interactions between the ligands and the receptor pocket. Biological potency of compounds 61, 72, and 86 (MRT-83) were comparable to those of the clinical candidate GDC-0449. These findings suggest that these original molecules will help delineate Smo and Hh functions and can be developed as potential anticancer agents.