313337-35-8

Usage

Uses

Used in Pharmaceutical Industry:
4-FLUORO-7-INDOLE CARBOXYLIC ACID METHYL ESTER is used as a pharmaceutical intermediate for its potential to be further processed or modified in the synthesis of various medicinal compounds. Its unique structural features and fluorine substitution contribute to its value in the development of new drugs.
Used in Drug Development:
4-FLUORO-7-INDOLE CARBOXYLIC ACID METHYL ESTER is utilized as an active pharmaceutical ingredient in the research and development of new therapeutic agents. Its properties may allow for the creation of drugs with improved pharmacokinetics, selectivity, and efficacy in treating specific medical conditions.
Used in Medicinal Chemistry Research:
4-FLUORO-7-INDOLE CARBOXYLIC ACID METHYL ESTER serves as a subject of study in medicinal chemistry, where its structure and properties are analyzed to understand its potential interactions with biological targets. This research can lead to the discovery of new drugs with novel mechanisms of action.

Upstream product

• 313337-34-7 4-fluoroindole-7-carboxylic acid 
• 313337-33-6 4-fluoro-1H-indole-7-carbonitrile 
• 292636-09-0 7-bromo-4-fluoro-1H-indole 
• 18107-18-1 diazomethyl-trimethyl-silane 

Relevant academic research and scientific papers

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

A series of substituted carboxamides at the indole C7 position of the previously described 4-fluoro-substituted indole HIV-1 attachment inhibitor 1 was synthesized and the SAR delineated. Heteroaryl carboxamide inhibitors that exhibited pM potency in the primary cell-based assay against a pseudotype virus expressing a JRFL envelope were identified. The simple methyl amide analog 4 displayed a promising in vitro profile, with its favorable HLM stability and membrane permeability translating into favorable pharmacokinetic properties in preclinical species.

Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with sulfonylureido piperazine derivatives of Formula I. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. 1wherein: Z is 2Q is selected from the group consisting of: 3—W— is 4—represents a carbon-carbon bond or does not exist; and A is NR13R14.

INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC UREIDO AND THIOUREIDO PIPERAZINE DERIVATIVES

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with ureido and thioureido piperazine derivatives of Formula (I). These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula (I) are Formula (I) wherein:Y is O or S;Z is Formula (II); Q is selected from the group consisting of Formula (A) and Formula (B); m is 2;A is NRR; and-W- is Formula (C).

Antiviral indoleoxoacetyl piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.