31334-63-1Relevant academic research and scientific papers
Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins
Gao, Mingchun,Zou, Minfen,Wang, Jue,Tan, Qitao,Liu, Bingxin,Xu, Bin
, p. 1593 - 1597 (2019)
A palladium-catalyzed multicomponent reaction of alkynes, carboxylic acids, and isocyanides has been developed with the assistance of silver salt under mild conditions. Highly functionalized captodative olefins are synthesized efficiently by this method, which can find many applications as versatile synthons in organic synthesis.
Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture
Steuer, Christian,Gege, Christian,Fischl, Wolfgang,Heinonen, Karl H.,Bartenschlager, Ralf,Klein, Christian D.
supporting information; experimental part, p. 4067 - 4074 (2011/08/21)
The development of small molecule inhibitors of the viral protease is of considerable interest for the treatment of emergent flaviviral diseases such as Dengue or West Nile fever. Until today little progress has been made in finding drug-like compounds th
