313352-59-9Relevant academic research and scientific papers
N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition
Chinthaginjala, Srinivasulu,Alavandimat, Nanda H.,Umesha, Vathsala,Sureshbabu, Vommina V.
supporting information, p. 2975 - 2983 (2021/08/27)
An efficient and facile method has been developed for the synthesis of chiral β-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of β-amino alcohols in excellent y
Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study
Yan, Shunqi,Appleby, Todd,Larson, Gary,Wu, Jim Z.,Hamatake, Robert K.,Hong, Zhi,Yao, Nanhua
, p. 1991 - 1995 (2008/02/04)
A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allosteric site. In particular, the designed molecules contain moieties of previously described thiazolone and a newly designed acylsulfonamide linker that is in turn connected with a substituted aromatic ring. The selected compounds were synthesized and demonstrated low μM activity. The X-ray complex structure was determined at a 2.2 A resolution and converged with the SBDD principle.
