313353-90-1

Upstream product

• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 104-94-9 4-methoxy-aniline 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 

Downstream Products

• 1334287-97-6 (S)-4-methoxy-N-(2,2,2-trifluoro-1-(p-tolyl)ethyl)aniline 
• 1313758-30-3 (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(p-tolyl)-propanenitrile 
• 1263499-16-6 (S)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(p-tolyl)propanenitrile 

Relevant academic research and scientific papers

Catalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-triflu

Internally Reuse Waste: Catalytic Asymmetric One-Pot Strecker Reaction of Fluoroalkyl Ketones, Anilines and TMSCN by Sequential Catalysis

We report a highly enantioselective one-pot facile synthesis of fluorinated Cα-tetrasubstituted amino nitriles from α-fluoroalkyl α-aryl ketones, anilines, and TMSCN through a sequential p-TsOH catalyzed ketimine formation and chiral bifunction

Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines

The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.

Chiral phosphoric acid catalyzed transfer hydrogenation: Facile synthetic access to highly optically active trifluoromethylated amines

Amines to an end: Highly optically active α-CF3- functionalized amines can be obtained using metal-free reaction conditions. The method involves the transfer hydrogenation of CF3-substituted ketimines catalyzed by 1 and reductive ami