313365-36-5Relevant academic research and scientific papers
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1
Shang, Erchang,Wu, Yiran,Liu, Pei,Liu, Ying,Zhu, Wei,Deng, Xiaobing,He, Chong,He, Shan,Li, Cong,Lai, Luhua
, p. 2764 - 2767 (2014/06/09)
A series of 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide analogues were synthesized and evaluated for their inhibition activity against 5-lipoxygenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES-1). These compounds can inhibit both enzymes with IC50 values ranging from 0.15 to 23.6 μM. One of the most potential compounds, 3g, inhibits 5-LOX and mPGES-1 with IC50 values of 0.6 μM, 2.1 μM, respectively.
