313381-77-0Relevant academic research and scientific papers
Versatile three-component synthesis of 2'-amino-1,2-dihydrospiro[(3H)- indole-3,4'-(4'H)-pyran]-2-ones
Mortikov,Litvinov,Shestopalov,Rodinovskaya,Shestopalov
experimental part, p. 2373 - 2380 (2010/02/16)
A versatile method for the synthesis of 2'-amino-1,2-dihydrospiro[(3H)- indole-3,4'-(4'H)-pyran]-2-ones has been suggested consisting in the three-component reaction of isatins, cyanoacetic acid derivatives, and α-methylenecarbonyl compounds (β-dicarbonyl compounds, activated phenols, and OH-substituted heterocycles) in ethanol in the presence of triethylamine as a catalyst. The reaction proceeds selectively to form spiro[(3H)-indole-3,4'-(4'H)-pyrans].
