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N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide, also known as Reversan, is a novel compound that belongs to a new class of non-toxic MRP1 inhibitors. It has the potential to be clinically useful in the treatment of neuroblastoma, a type of cancer commonly associated with the overexpression of MRP1 proteins.
Used in Pharmaceutical Industry:
N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide is used as a non-toxic MRP1 inhibitor for the treatment of neuroblastoma. Its ability to inhibit MRP1 proteins makes it a promising candidate for addressing the challenges posed by multidrug resistance in cancer treatment. By targeting MRP1, Reversan can potentially enhance the effectiveness of conventional chemotherapy and improve patient outcomes.

313397-13-6

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313397-13-6 Usage

Biological Activity

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.

Check Digit Verification of cas no

The CAS Registry Mumber 313397-13-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,3,3,9 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 313397-13:
(8*3)+(7*1)+(6*3)+(5*3)+(4*9)+(3*7)+(2*1)+(1*3)=126
126 % 10 = 6
So 313397-13-6 is a valid CAS Registry Number.

313397-13-6 Well-known Company Product Price

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  • Sigma

  • (SML0173)  Reversan  ≥98% (HPLC)

  • 313397-13-6

  • SML0173-5MG

  • 1,171.17CNY

  • Detail

  • Sigma

  • (SML0173)  Reversan  ≥98% (HPLC)

  • 313397-13-6

  • SML0173-25MG

  • 4,737.33CNY

  • Detail

313397-13-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(3-morpholin-4-ylpropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

1.2 Other means of identification

Product number -
Other names N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:313397-13-6 SDS

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