313504-94-8Relevant academic research and scientific papers
Synthesis and biological evaluation of a series of (Benzo[d]thiazol-2-yl) cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides
Nam, Nguyen Hai,Dung, Phan Thi Phuong,Thuong, Phuong Thien,Hien, Tran Thi
experimental part, p. 159 - 164 (2011/08/10)
A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl) cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl) cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compo
Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents
Yoshida, Masao,Hayakawa, Ichiro,Hayashi, Noriyuki,Agatsuma, Toshinori,Oda, Youko,Tanzawa, Fumie,Iwasaki, Shiho,Koyama, Kumiko,Furukawa, Hidehiko,Kurakata, Shinichi,Sugano, Yuichi
, p. 3328 - 3332 (2007/10/03)
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2- (cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2- (cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
