313545-32-3

Usage

Uses

Used in Suzuki Reaction:
2-Chloro-6-fluorophenylboronic acid is used as a reactant in the Suzuki coupling reaction, a widely employed method for the formation of carbon-carbon bonds in organic synthesis. It serves as a nucleophile to form new bonds with electrophilic partners, enabling the synthesis of various biaryl compounds with potential applications in pharmaceuticals, agrochemicals, and materials science.
Used in Preparation of Cellular Checkpoint Kinase Wee1 Binding Affectors:
2-Chloro-6-fluorophenylboronic acid is used as a key intermediate in the synthesis of cellular checkpoint kinase Wee1 binding affectors. These affectors are important for the development of potential therapeutic agents targeting the Wee1 kinase, which plays a crucial role in cell cycle regulation and has been implicated in various cancers. The unique substitution pattern of the compound allows for the creation of specific binding interactions with the target protein, contributing to the development of more effective and selective inhibitors.

Upstream product

• 121-43-7 Trimethyl borate 
• 625-98-9 3-chlorofluorobenzene 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 2225909-61-3 8-bromo-1-chlorodibenzo[b,d]furan 
• 1599432-38-8 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1586041-22-6 N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 
• 1586041-18-0 5-amino-N-(5-((2S,5R,6R)-5-amino-6-methoxyoxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 
• 1586041-65-7 5-amino-N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 

Relevant academic research and scientific papers

1' - Chloro -8 - bromine two benzofuran preparation method (by machine translation)

The invention discloses a high-efficient environmental protection of the 1 '- chloro - 8 - bromine two benzofuran preparation method, including: (1) butyl [...] chlorobenzene firstly the lithium pulls out the hydrogen, with triisopropyl borate undergo the

Expanding the Boundaries of Water-Tolerant Frustrated Lewis Pair Hydrogenation: Enhanced Back Strain in the Lewis Acid Enables the Reductive Amination of Carbonyls

The development of a boron/nitrogen-centered frustrated Lewis pair (FLP) with remarkably high water tolerance is presented. As systematic steric tuning of the boron-based Lewis acid (LA) component revealed, the enhanced back-strain makes water binding increasingly reversible in the presence of relatively strong base. This advance allows the limits of FLP's hydrogenation to be expanded, as demonstrated by the FLP reductive amination of carbonyls. This metal-free catalytic variant displays a notably broad chemoselectivity and generality.