313545-72-1

Basic information

• Product Name: 2-CHLORO-4-FLUOROPHENYLBORONIC ACID
• Synonyms: AKOS BRN-0714;2-CHLORO-4-FLUOROPHENYLBORONIC ACID;2-CHLORO-4-FLUOROBENZENEBORONIC ACID;2-Cholro-4-flurophenylboronic acid;2-Chloro-4-fluorobenzeneboronic acid 98%;2-Chloro-4-fluorobenzeneboronicacid98%;2-CHLORO-4-FUOROPHENYLBORONICACID;1-Borono-2-chloro-4-fluorobenzene
• CAS NO: 313545-72-1
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Aryl;Fluorinated;Organoborons;Boronic acid
• Mol File: 313545-72-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 220-223
• Boiling Point: 290.904 °C at 760 mmHg
• Flash Point: 129.735 °C
• Appearance: White/Crystalline Powder
• Density: 1.416 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.37±0.58(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-FLUOROPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-FLUOROPHENYLBORONIC ACID(313545-72-1)
• EPA Substance Registry System: 2-CHLORO-4-FLUOROPHENYLBORONIC ACID(313545-72-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-36-39-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 313545-72-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C6H5BClFO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3,10-11H

Upstream product

• 121-43-7 Trimethyl borate 
• 101335-11-9 2-chloro-4-fluoro-1-iodobenzene 

Downstream Products

• 444663-87-0 1-(2,6-dichlorophenyl)-5-(2-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone 
• 444663-60-9 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-7-methoxy-3,4-dihydro-1H-quinolin-2-one 
• 1024500-33-1 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(2-hydroxyethyl)-quinolin-2(1H)-one 
• 1024500-41-1 C₂₉H₂₃Cl₃FNO₃ 
• 1248738-03-5 [3-(2-chloro-4-fluorophenyl)-2-pyridinyl]methanol 
• 1242016-00-7 4-[[4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl]oxy]-3,5-difluorobenzonitrile 
• 864830-09-1 tert-butyl 4-(2-chloro-4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate 
• 1310359-73-9 ethyl 4-(2-chloro-4-fluorophenyl)-6-methoxy-1,5-naphthyridine-3-carboxylate 
• 1310359-85-3 ethyl 4-(2-chloro-4-fluorophenyl)-6-oxo-5,6-dihydro-1,5-naphthyridine-3-carboxylate 
• 1227076-88-1 2-(2-chloro-4-fluorophenyl)pyridine 
• 1512812-02-0 7-fluoro-5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine 
• 1620515-98-1 5-(2-chloro-4-fluorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine 
• 1079400-13-7 N-(6-amino-5-(2-chloro-4-fluorophenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Synthesis of Biphenylenes and Their Higher Homologues by Cyclization of Aryne Derivatives

This investigation demonstrates that a series of biphenylenes can be easily prepared from their corresponding halobiphenyls by the cyclization of in situ generated 2′,3′-didehydro-2-lithiobiphenyls at low temperature. Two remarkable advantages of this synthetic method include 1) the lack of any need for transition-metal catalysts or reagents in the cyclization, and 2) the ability to obtain C1-functionalized products by treating the reaction intermediate 1-lithiobiphenylene with an electrophilic reagent. π-Extended derivatives, such as benzobiphenylenes, dibenzobiphenylene, linear/angular [3]phenylenes, and biphenyleno[2,3-b]biphenylenes, were synthesized similarly using suitable biaryls or teraryls.