31357-83-2

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 39831-11-3 Bis-(α-methyl-β-formyl-β-phenyl-vinyl)-sulfid 
• 133205-43-3 7-methyl-6-phenyl-2,3-dihydro-1,4-thiazepine 
• 49602-70-2 5-Methyl-4-phenyl-1,2-thiazol 
• 39831-33-9 [6-Methyl-5-phenyl-thiopyran-(2E)-ylidene]-phenyl-acetaldehyde 
• 100475-87-4 (2-Methyl-[1,3]dioxolan-2-yl)-phenyl-acetaldehyde 
• 81187-29-3 2-methyl-1,3,5-triphenyl-1H-1,5-diazapentadienium perchlorate 
• 131124-14-6 Phenyl-[5-phenyl-6-trifluoromethyl-thiopyran-(2Z)-ylidene]-acetaldehyde 
• 77831-63-1 4-Diethylamino-3-phenyl-3-buten-2-one 
• 62404-01-7 C₁₄H₁₄O₂S 
• 1567463-19-7 2-diethoxyphosphoryl-3-methyl-4-phenylthiophene 
• 142144-59-0 [6-Nitro-thiochromen-(2Z)-ylidene]-phenyl-acetaldehyde 
• 87360-54-1 Phenyl-[6-phenyl-thiopyran-(2Z)-ylidene]-acetaldehyde 
• 87360-57-4 [6-(4-Chloro-phenyl)-thiopyran-(2Z)-ylidene]-phenyl-acetaldehyde 
• 87360-65-4 Phenyl-[6-phenyl-selenopyran-(2Z)-ylidene]-acetaldehyde 

Relevant academic research and scientific papers

On the regio and stereo selective formylations of acyclic alpha methylene ketones towards Vilsmeier Haack reagent

The regio and stereo selectivities of Vilsmeier Haack reaction of ketomethylene compounds have been predicted. The possible mechanistic pathway has also been proposed.

Titanacyclobutenes or titanium vinyl carbene complexes? Reactivity of organotitanium species generated by the reaction of γ-chloroallyl sulfides with a titanocene(II) reagent

The reactivity of the organotitanium species generated by the reductive titanation of γ-chloroallyl sulfides with the titanocene(II) reagent [Cp2Ti{P(OEt)3}2] was studied. The organotitanium species formed from α-monosubstituted γ-chloroallyl sulfides reacted with 1,5-diphenylpentan-3-one and styrene to produce conjugated dienes and vinyl cyclopropanes as major products, thus suggesting the formation of vinyl carbene complexes as intermediates. On the contrary, the organotitanium species generated from acyclic β,γ-disubstituted γ-chloroallyl sulfides revealed titanacyclobutene-like reactivity, and their reaction with 1,5-diphenylpentan-3-one produced homoallyl alcohols. These organotitanium species did not react with styrene, but did react with dichlorophenylphosphine to afford phosphacyclobutenes. In the case of β-monosubstituted, γ-monosubstituted, and α,γ- disubstituted γ-chloroallyl sulfides, the organotitanium species reacted with both 1,5-diphenylpentan-3-one and styrene. The former reaction produced homoallyl alcohols and the latter gave vinyl cyclopropanes or unconjugated dienes. These results suggest that titanacyclobutenes and/or titanium vinyl carbene complexes are produced by the reductive titanation of γ-chloroallyl sulfides depending on their substitution patterns.

NOVEL THIOPHENE DERIVATIVES

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

Synthesis of β-chloro(trifluoromethyl)acroleins and a specific reaction towards β-aminothiols

β-chloro-β-(trifluoromethyl)acroleins and β-chloro-α-(trifluoromethyl)-acrolein have been synthesized through Vilsmeier's reaction. A specific 1,4-addition of the nitrogen atom from β-aminothiols is observed.