313654-83-0

Basic information

• Product Name: 3'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate;2']bipyrazinyl-4-carboxylic acid tert-butyl ester;3'-Chloro-2;6-tetrahydro-[1;2-Chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine;4-(3-chloro-2-pyrazinyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(3-chloropyrazin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 313654-83-0
• Molecular Formula: C₁₃H₁₉ClN₄O₂
• Molecular Weight: 298.77
• Mol File: 313654-83-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 412.8°Cat760mmHg
• Flash Point: 203.4°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 5.06E-07mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(313654-83-0)
• EPA Substance Registry System: 3'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER(313654-83-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 313654-83-0(Hazardous Substances Data)

Usage

Uses

3''-Chloro-2,3,5,6-tetrahydro-[1,2'']bipyrazinyl-4-carboxylic Acid tert-Butyl Ester

InChI:InChI=1/C13H19ClN4O2/c1-13(2,3)20-12(19)18-8-6-17(7-9-18)11-10(14)15-4-5-16-11/h4-5H,6-9H2,1-3H3

Upstream product

• 4858-85-9 2,3-dichloropyrazine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 651047-29-9 3-(4-tert-butoxycarbonyl-1-piperazinyl)-2 (1H)-pyrazinone 
• 313658-37-6 tert-Butyl 4-{3-[(2-hydroxyethyl)sulfanyl]-2-pyrazinyl}-1-piperazinecarboxylate 
• 1143517-79-6 3'-piperidin-1-yl-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid t-butyl ester 
• 1082063-19-1 2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride 
• 1082063-12-4 {4-[4-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-3'-yl]-phenyl}-methanol hydrochloride 
• 1082063-65-7 methyl 4-(3-(4-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)pyrazin-2-yl)benzoate hydrochloride 
• 1082066-12-3 3'-chloro-4-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine 
• 1082066-14-5 2-[4-(3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl)-pyrazol-1-yl]-ethanol 
• 1082066-10-1 3'-chloro-4-(1,3-dimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine 
• 1082065-40-4 4-(3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-3'-yl)-benzonitrile 
• 1082066-11-2 3'-chloro-4-(1-methyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine 
• 1082065-20-0 3'-m-tolyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine 
• 1377550-27-0 5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine 
• 1377551-51-3 2-(4-methoxyphenyl)-3-(4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl)piperazin-1-yl)pyrazine 

Relevant articles and documents

NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula (I) and their use in the treatment of migraine: where A is C(H)= or N=; m is 0, 1 or 2; R1 is optionally substituted phenyl, optionally substituted pyrazol-4-yl; optionally substituted imidazolyl, optionally substituted pyridyl, or thienyl; R2 is hydrogen or methyl; and R3 and R4 are as defined herein.

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.