313662-36-1Relevant academic research and scientific papers
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
Song, Eun Young,Kaur, Navneet,Park, Mi-Young,Jin, Yinglan,Lee, Kyeong,Kim, Guncheol,Lee, Ki Youn,Yang, Jee Sun,Shin, Jae Hong,Nam, Ky-Youb,No, Kyoung Tai,Han, Gyoonhee
, p. 1519 - 1524 (2008)
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
