313674-12-3

Basic information

• Product Name: 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID
• Synonyms: 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID;2-chloro-4-(1H-pyrazol-1-yl)benzoic acid
• CAS NO: 313674-12-3
• Molecular Formula: C₁₀H₇ClN₂O₂
• Molecular Weight: 222.63
• Mol File: 313674-12-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 210-213°C
• Appearance: /
• CAS DataBase Reference: 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID(313674-12-3)
• EPA Substance Registry System: 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID(313674-12-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 313674-12-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID is a chemical compound with the molecular formula C11H8ClN3O2. It is a carboxylic acid derivative containing a chloro group and a pyrazole ring. This chemical may be used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Additionally, it can be employed as a reagent in organic synthesis for the preparation of diverse functionalized compounds. Its structural features make it a valuable intermediate in medicinal chemistry and organic chemistry research.

Upstream product

• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 
• 313674-09-8 2-chloro-4-(pyrazol-1-yl)benzoic acid methyl ester 

Downstream Products

• 530089-23-7 methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate 
• 911312-88-4 2-chloro-4-pyrazol-1-ylbenzoyl chloride 

Relevant articles and documents

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.

Novel design of nonpeptide AVP V2 receptor agonists: Structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a template

The discovery of a series of nonpeptide arginine vasopressin V2 receptor agonists is described. After identifying the aniline derivative 8 as our lead compound from the metabolites of compound 7 that showed antidiuretic activity by po administr