313674-12-3

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceuticals. Its structural components, including the chloro and pyrazole groups, contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID is utilized as a key component in the creation of agrochemicals. Its properties allow for the formulation of compounds that can be used in crop protection and other agricultural applications.
Used in Organic Synthesis:
2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID is employed as a reagent in organic synthesis. It aids in the preparation of diverse functionalized compounds, which can be further utilized in various chemical reactions and processes.
Used in Medicinal Chemistry Research:
As a valuable intermediate, 2-CHLORO-4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLIC ACID is used in medicinal chemistry research to explore its potential in the development of new therapeutic agents and to understand its interactions with biological targets.

Upstream product

• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 
• 313674-09-8 2-chloro-4-(pyrazol-1-yl)benzoic acid methyl ester 

Downstream Products

• 911312-88-4 2-chloro-4-pyrazol-1-ylbenzoyl chloride 
• 530089-23-7 methyl (2Z)-{1-[2-chloro-4-(1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate 

Relevant academic research and scientific papers

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.

4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF

4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.

Novel design of nonpeptide AVP V2 receptor agonists: Structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a template

The discovery of a series of nonpeptide arginine vasopressin V2 receptor agonists is described. After identifying the aniline derivative 8 as our lead compound from the metabolites of compound 7 that showed antidiuretic activity by po administr