313676-60-7Relevant academic research and scientific papers
The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors
Simons, Lloyd J.,Caprathe, Bradley W.,Callahan, Michael,Graham, James M.,Kimura, Takenori,Lai, Yingjie,LeVine III, Harry,Lipinski, William,Sakkab, Annette T.,Tasaki, Yoshikazu,Walker, Lary C.,Yasunaga, Tomoyuki,Ye, Yuyang,Zhuang, Nian,Augelli-Szafran, Corinne E.
scheme or table, p. 654 - 657 (2009/09/06)
It is believed that β-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify β-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for β-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
-
, (2008/06/13)
The present invention provides a method of treating Alzheimer's disease using a compound of Formula I Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits, as we
