31386-36-4Relevant academic research and scientific papers
Carvacrol codrugs: A new approach in the antimicrobial plan
Cacciatore, Ivana,Di Giulio, Mara,Fornasari, Erika,Di Stefano, Antonio,Cerasa, Laura Serafina,Marinelli, Lisa,Turkez, Hasan,Di Campli, Emanuela,Di Bartolomeo, Soraya,Robuffo, Iole,Cellini, Luigina
, (2015/06/02)
Objective: The increasing prevalence of antibiotic-resistant bacterial infections led to identify alternative strategies for a novel therapeutic approach. In this study, we synthesized ten carvacrol codrugs - obtained linking the carvacrol hydroxyl group
An improved method for cysteine alkylation
Perrey, David A.,Uckun, Fatih M.
, p. 1859 - 1861 (2007/10/03)
An improved method for the synthesis of S-alkylated cysteine derivatives with branched alkyl chains is reported. These compounds can be obtained in good yield and high purity by refluxing the cysteine thiol with the appropriate alkyl bromide in a solution of sodium ethoxide in ethanol.
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds
Perrey, David A.,Scannell, Michael P.,Narla, Rama Krishna,Uckun, Fatih M.
, p. 551 - 552 (2007/10/03)
A series of cysteine chloromethyl ketone compounds with a systematic variation of the S-alkyl chain length have been synthesized in order to gauge the effect of the alkyl chain length on the cytotoxicity of these compounds against human acute lymphoblastic leukemia cells. Comparable activities were observed for compounds with S-alkyl chains ranging from pentyl to dodecyl, with the best being undecyl (IC50 = 1.7 μM) and dodecyl (IC50 = 2.0 μM) against B-lineage leukemia cells and hexyl (IC50 = 0.7 μM) against T-lineage leukemia cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
