313963-29-0Relevant academic research and scientific papers
Total synthesis of (-)-goniotrionin
Dias, Luiz C.,Ferreira, Marco A. B.
experimental part, p. 4046 - 4062 (2012/06/29)
A stereoselective total synthesis of the reported structure of goniotrionin (4) has been accomplished. The key steps involved the opening of a chiral epoxide, a highly diastereoselective Mukaiyama aerobic oxidative cyclization, a selective 1,2-syn Mukaiyama aldol reaction, and a Noyori reduction.
Syntheses of epi-aigialomycin D and deoxy-aigialomycin C via a diastereoselective ring closing metathesis macrocyclization protocol
Bajwa, Naval,Jennings, Michael P.
, p. 390 - 393 (2008/09/17)
Syntheses of epi-aigialomycin D and deoxy-aigialomycin C are described via a remote stereocontrolled RCM macrocyclization.
The total synthesis of the annonaceous acetogenin, muricatetrocin C
Dixon, Darren J.,Ley, Steven V.,Reynolds, Dominic J.
, p. 1621 - 1636 (2007/10/03)
The total synthesis of the potential antitumour agent muricatetrocin C has provided an ideal stage for the exploitation and development of new chemistry. A convergent synthetic strategy has been realised incorporating three distinct pieces of methodology, these include a highly diastereoselective hetero-Diels -Alder reaction to construct the butenolide terminus, an oxygen to carbon rearrangement to install the trans-2,5-disubstituted tetrahydrofuran ring and a spatial desymmetrisation process to afford the anti-diol unit.
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
Dixon,Ley,Reynolds,Chorghade
, p. 1043 - 1053 (2007/10/03)
A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 has been accomplished, utilising an oxygen to carbon rearrangement of an anomerically linked alkynyl stannane tetrahydrofuranyl ether derivative as the key step.
