313967-18-9

Basic information

• Product Name: FLI-06
• Synonyms: FLI-06;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor
• CAS NO: 313967-18-9
• Molecular Formula: C25H30N2O5
• Molecular Weight: 438.5161
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 313967-18-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 597.5±50.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble5mg/mL, clear (warmed)
• PKA: 0.78±0.70(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
• CAS DataBase Reference: FLI-06(CAS DataBase Reference)
• NIST Chemistry Reference: FLI-06(313967-18-9)
• EPA Substance Registry System: FLI-06(313967-18-9)

Safety Data

• RIDADR: 3077
• WGK Germany: 3
• Hazardous Substances Data: 313967-18-9(Hazardous Substances Data)

Usage

Description

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1

Uses

FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.

References

1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731