6-[(1-NaphthalenylMethyl)thio]-9H-purine, also known as PU 02, is a compound that acts as an antagonist of the serotonin (5-HT) receptor subtype 5-HT3. It exhibits high selectivity for the 5-HT3 receptor over other Cys-loop containing receptors and has been shown to inhibit currents induced by 5-HT in cells expressing the human 5-HT3A receptor. Additionally, PU 02 has been demonstrated to reduce the growth of HepG2 cells in a dose-dependent manner through the induction of cell cycle arrest at the G2/M phase and apoptosis.
313984-77-9
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Basic information
- Product Name: 6-[(1-NaphthalenylMethyl)thio]-9H-purine
- Synonyms: 6-[(1-NaphthalenylMethyl)thio]-9H-purine;PU 02;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine
- CAS NO:313984-77-9
- Molecular Formula: C16H12N4S
- Molecular Weight: 292.35828
- EINECS: N/A
- Product Categories: N/A
- Mol File: 313984-77-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: 6-[(1-NaphthalenylMethyl)thio]-9H-purine(CAS DataBase Reference)
- NIST Chemistry Reference: 6-[(1-NaphthalenylMethyl)thio]-9H-purine(313984-77-9)
- EPA Substance Registry System: 6-[(1-NaphthalenylMethyl)thio]-9H-purine(313984-77-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 313984-77-9(Hazardous Substances Data)
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313984-77-9 Usage
Uses
Used in Pharmaceutical Industry:6-[(1-NaphthalenylMethyl)thio]-9H-purine is used as a therapeutic agent for the treatment of conditions related to the serotonin (5-HT) receptor subtype 5-HT3. Its high selectivity for the 5-HT3 receptor makes it a promising candidate for the development of drugs targeting this receptor, potentially leading to novel treatments for various disorders.
Used in Cancer Research:
In the field of cancer research, 6-[(1-NaphthalenylMethyl)thio]-9H-purine is used as a compound to study its effects on the growth of cancer cells, specifically HepG2 cells. Its ability to induce cell cycle arrest and apoptosis suggests potential applications in the development of anti-cancer drugs or therapies.
Used in Neuropharmacology:
6-[(1-NaphthalenylMethyl)thio]-9H-purine is used as a research tool in neuropharmacology to investigate the role of the serotonin (5-HT) receptor subtype 5-HT3 in various neurological and psychiatric conditions. Understanding the interactions between PU 02 and the 5-HT3 receptor can provide insights into the development of new treatments for conditions such as anxiety, depression, and other disorders involving the serotonin system.
Used in Drug Development:
In the drug development industry, 6-[(1-NaphthalenylMethyl)thio]-9H-purine serves as a lead compound for the design and synthesis of new drugs targeting the serotonin (5-HT) receptor subtype 5-HT3. Its high selectivity and potency make it an attractive starting point for the development of more effective and safer medications for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 313984-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,3,9,8 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.Calculate Digit Verification of CAS Registry Number 313984-77:
(8*3)+(7*1)+(6*3)+(5*9)+(4*8)+(3*4)+(2*7)+(1*7)=159
159 % 10 = 9
So 313984-77-9 is a valid CAS Registry Number.
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6-[(1-NaphthalenylMethyl)thio]-9H-purine
