31401-59-9

Upstream product

• 85600-11-9 N-Benzylammonium-N'-benzylcarbaminat 
• 123-08-0 4-hydroxy-benzaldehyde 
• 62-53-3 aniline 
• 100-46-9 benzylamine 

Downstream Products

• 52447-51-5 4-[(benzylamino)methyl]phenol 

Relevant academic research and scientific papers

Synthesis and characterization of Ni(II) complexes with functionalized dithiocarbamates: New single source precursors for nickel sulfide and nickel-iron sulfide nanoparticles

Six Ni(II) complexes, bis(N-benzyl-N-substituted benzyldithiocarbamato-S,S′)nickel(II) (1–3), (N-benzyl-N-substituted benzyldithiocarbamato-S,S′)(thiocyanato-N)(triphenylphosphine)nickel(II) (4–6), [Substituted benzyl=4-hydroxybenzyl (1, 4), 4-methoxybenzyl (2, 5), 4-chlorobenzyl (3, 6)] complexes have been synthesized and characterized by elemental analysis, IR, UV–Vis and NMR (1H and 13C) spectroscopy. Upfield shift of NCS2 carbon signals of heteroleptic complexes compared to homoleptic complexes supports the back bonding effect of triphenylphosphine. Structures of complexes 1, 4, 5 and 6 have been obtained by single crystal X-ray diffraction. The coordination geometry around nickel is a distorted square planar in all the complexes. Intramolecular Ni?H-C anagostic interaction is observed in 4. Various non-covalent interactions such as C-H?π(chelate), C-H?π and C-H?X (X = O and Cl) lead to supramolecular aggregation. [Ni(dbdtc)2] and [Ni(dbdtc)3][FeCl4] (dbdtc = N,N-dibenzyldithiocarbamate) were used to prepare monometallic sulfide (nickel sulfide), bimetallic sulfide (iron-nickel sulfide) nanoparticles. TEM images of nickel sulfide and iron-nickel sulfide reveal that the particles are oval shape and ultrafine (～5–10 nm), respectively.

Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel: S -triazine derivatives

In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using an s-triazine scaffold, via amine and Schiff base derivatives, has been developed. In order to obtain antitumor activity, all synthesized compounds were screened in vitro for their cytotoxicity against human fibrosarcoma tumor cells (HT-1080) and a cervical cancer cell line (HeLa), for their ability to inhibit the growth of cancer cells. The selected s-triazine analogs (5c, 5d, and 6c) have been preliminarily studied for their reactive oxygen species (ROS) properties, mitochondrial membrane potential (MMP) and apoptosis (AO/EtBr) activity against the HT-1080 cancer cell line. The in vitro anticancer activity analysis has revealed that the synthesized compounds have good/moderate inhibitory activity against the tested cell lines compared to the standard drug. The theoretical study results also provide evidence that the s-triazines scaffolds have been successfully identified as superior p53-MDM2 inhibitors through structure-based design.

Selectively catalytic epoxidation of α-pinene with dry air over the composite catalysts of Co-MOR(L) with Schiff-base ligands

Twelve bi-/tridentate Schiff-base ligands (L1-L12) have been designed, synthesized and coordinated with ion-exchanged Co-MOR (Mordenite) forming a series of Co-MOR(L) composite catalysts, for which various analyzes and characterizations are conducted. Selectively catalytic epoxidation of α-pinene with dry air over Co-MOR(L) catalysts has been carried out, where uses TBHP in small amounts as the initiator. Among these Co-MOR(L) catalysts, Co-MOR(L8) exhibits the best activity for the titled reaction to obtain 85.8 mol% conversion and 90.8% selectivity of epoxide. Some factors such as the structure of ligands, the oxidants, the solvents, the catalyst amount, the reaction temperature and time play important roles in controlling the epoxidation. The recyclable stability of the Co-MOR(L8) catalyst is confirmed. The studies on the electrochemical behaviors of Co species in Co-MOR(L8) reveal the importance of reversible change between Co oxidation states for the epoxidation.

Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives

A series of new aculeatin-like analogues were synthesized in two steps by combining two sets of building blocks. Many compounds showed inhibitory activities in vitro against Plasmodium falciparum and have helped to gain more insight into structure-activit

Direct synthesis of imines via solid state reactions of carbamates with aldehydes

Various solid carbamates were prepared from the reactions of liquid amines with carbon dioxide in an autoclave and these carbamates were used as stable, efficient alternatives for toxic liquid amines. Solid-state grinding of carbamates and aldehydes, using a mortar and pestle, produced imines as the sole products in greater than 97% yields. Complete conversions were generally accomplished within a day at 25 °C without using solvents or additives. Reaction rates were drastically enhanced upon increasing the reaction temperature. In contrast, reactions of aldehydes with liquid amines in the presence of solvent or in neat conditions afforded imines in moderate yields along with by-products.

Chitosan: A highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions

Commercial chitosan-without any post-modification with active Bronsted or Lewis acid centers-was found to be a highly efficient renewable and recoverable bio-polymer catalyst for the rapid and convenient synthesis of α-amino nitriles or imines from aromatic aldehydes and amines under mild reaction conditions at room temperature in high to quantitative yields. The α-amino nitrile derivatives were prepared through the Strecker reaction using trimethylsilyl cyanide (TMSCN) and catalyzed by chitosan as a heterogeneous bifunctional organocatalyst.