314020-40-1

Basic information

• Product Name: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide
• Synonyms: 2-(2,6-Diethyl-4-methylphenyl)malonamide; propanediamide, 2-(2,6-diethyl-4-methylphenyl)-
• CAS NO: 314020-40-1
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Mol File: 314020-40-1.mol

Chemical Properties

• Boiling Point: 450.8°C at 760 mmHg
• Flash Point: 226.4°C
• Density: 1.113g/cm³
• Vapor Pressure: 2.57E-08mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)
• EPA Substance Registry System: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)

Safety Data

• Hazardous Substances Data: 314020-40-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,6-diethyl-4-methyl-phenyl)propanediamide is utilized as a pharmaceutical intermediate for the synthesis of various drugs, including analgesics and anti-inflammatory medications. Its structural properties allow it to be a key component in the development of medications aimed at alleviating pain and reducing inflammation.
Used in Organic Chemistry:
In the realm of organic chemistry, 2-(2,6-diethyl-4-methyl-phenyl)propanediamide is employed as a building block for the synthesis of more complex molecules. Its ability to be integrated into larger chemical structures makes it a valuable asset in the creation of advanced organic compounds for a variety of applications.
While the exact properties and applications of 2-(2,6-diethyl-4-methyl-phenyl)propanediamide are not extensively studied or documented, its potential for use in other industries such as materials science, chemical research, or as a component in specialized formulations, remains an open area for further exploration and development.

Upstream product

• 24544-08-9 2,6-diethyl-4-methylaniline 
• 314020-53-6 2-(2,6-diethyl-4-methylbenzene)malononitrile 
• 314084-61-2 1-bromo-2,6-diethyl-4-methylbenzene 

Downstream Products

• 243973-20-8 pinoxaden 
• 1416807-67-4 8-(2,6-diethyl-4-methylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione 

Relevant articles and documents

Conjugated triene compound and preparation method and application thereof

The invention provides a novel conjugated triene compound 1 and a preparation method and application thereof. By taking a 2-(cyclohexenyl) malonic acid derivative compound as a raw material, isomerization reaction, halogenation reaction in the presence of a halogenation reagent and dehydrohalogenation reaction at a certain temperature are sequentially carried out to obtain a conjugated triene compound 1; 2-aryl malonic acid derivative obtained by aromatization reaction of the conjugated triene compound 1 can be applied to synthesis of compounds with biological activity. The invention has the following remarkable characteristics and advantages: (1) the invention provides a novel conjugated triene compound 1 and a synthetic method thereof; and (2) the new compound 1 with the multifunctionalgroup can be used for synthesizing other compounds with important values through further functional group conversion reaction.

METHOD FOR PREPARING 2-ARYL MALONAMIDE AND APPLICATIONS THEREOF

Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production.

Method for preparing 2-arylmalonic acid derivative, intermediate and application thereof

The invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate and application thereof. According to the method, a cyclohexadiene compound is used as a raw material, and the 2-arylmalonic acid derivative 3 is obtained through an isomerization reaction, a halogenation reaction in the presence of a halogenation reagent and a dehydrohalogenation aromatization reactionat a certain temperature in sequence. Compared with the prior art, the method has the following remarkable characteristics and advantages: (1) expensive metal catalysts are not needed in the reaction;(2) strong base with potential safety hazards is not needed in the reaction; and (3) the reaction is safe, the conditions are mild, the yield is high, the cost is low, and industrial production is facilitated.

Halogenated conjugated diene compound and preparation method and application thereof

The invention provides a novel halogenated conjugated diene compound 1 as well as a preparation method and application thereof. A conjugated diene compound is used as a raw material and is subjected to halogenation reaction to obtain a compound 1. A 2-aryl malonic acid derivative obtained by dehydrohalogenation aromatization reaction of the compound 1 can be applied to synthesis of a compound withbiological activity. The invention has the following remarkable characteristics and advantages: (1) the invention provides a novel halogenated conjugated diene compound 1 and a synthetic method thereof; and (2) the new compound 1 with the multifunctional group can be used for synthesizing other compounds with important values through further functional group conversion reaction.

Method for preparing 2,6-diethyl-4-methylphenylmalonamide

The invention relates to a method for preparing 2,6-diethyl-4-methylphenylmalonamide. The method comprises the following steps: catalyzing 2,6-diethyl-4-methylphenylmalonitrile and water in a polar solvent by transition metal oxides to carry out a hydrolysis reaction, thereby obtaining the 2,6-diethyl-4-methylphenylmalonamide, wherein a molar ratio of the 2,6-diethyl-4-methylphenylmalonitrile to the transition metal oxides is 1:(0.001-3.0); and the reaction temperature is 10-250 DEG C. The invention further relates to application of the 2,6-diethyl-4-methylphenylmalonamide in preparation of anherbicide pinoxaden intermediate. According to the preparation method of the 2,6-diethyl-4-methylphenylmalonamide, the 2,6-diethyl-4-methylphenylmalonitrile is subjected to catalytic hydrolysis by using the transition metal oxides, the preparation method is high in reaction speed, high in selectivity, mild in reaction condition and environmental-friendly, further hydrolysis of the product 2,6-diethyl-4-methylphenylmalonamide can be effectively avoided, and the method is suitable for industrial production.

Method for preparing 2-aryl malonamide and application thereof

The invention provides a method for preparing 2-aryl malonamide and application thereof. According to the method, 2-(cyclohexadienylidene)malononitrile is used as a raw material and undergoes an aromatization-hydrolysis reaction under the action of an oxidizing agent and water so as to obtain 2-arylmalonamide in one step. Compared with the prior art, the method for preparing 2-arylmalonamide provided by the invention has the following remarkable features and advantages: (1) completely different synthesis strategies are adopted; (2) the raw material is simple and easily available; and (3) yieldis high, the use of expensive metal catalysts is avoided, cost is low, and the method is suitable for industrial production.

Preparation method and application of 2-aryl malonic acid derivative

The invention provides a preparation method and application of 2-aryl malonic acid derivative. The preparation method includes: using a cyclohexenone derivative as a raw material to be in condensationreaction with a malonic acid derivative at the presence of a catalyst A to obtain a 2-(cyclohexenylene) malonic acid derivative; enabling the 2-(cyclohexenylene) malonic acid derivative to be in aromatization reaction under action of a catalyst B to obtain the 2-aryl malonic acid derivative. Compared with the prior art, the preparation method is totally different from existing methods in synthesis strategy and used raw materials and has the advantages that reaction raw materials are easy to obtain; no solvent is needed during reaction, and yield is high; the catalyst B can be recycled, so that cost is lowered; the preparation method is high in yield, few in three wastes, environment-friendly and conducive to industrial production.

Preparation method of pinoxaden

The invention relates to a preparation method of pinoxaden. The preparation method comprises the following steps: carrying out sandmeyer reaction on 2,6-diethyl-4-methylaniline to obtain 2,6-diethyl-4-methylbromobenzene; then coupling the 2,6-diethyl-4-methylbromobenzene with malononitrile under the catalysis of copper iodide and the like to obtain 2,6-di-ethyl-4-methylphenyl malononitrile; finally, hydrolyzing in a hydrogen peroxide solution to obtain 2,6-diethyl-4-methylphenyl malonamide; afterwards, reacting the 2,6-diethyl-4-methylphenyl malonamide with [1,4,5]-oxa-diazepine dihydrobromide under the action of triethylamine to obtain 8-(2,6-diethyl-4-methyl benzene)tetrahydropyrazole [1,2d][1,4,5]-oxa-diazepine-7,9-dione, and finally reacting the 8-(2,6-diethyl-4-methyl benzene) tetrahydropyrazole[1,2d][1,4,5]-oxdiazepine-7,9-dione with pivalyl chloride to obtain the pinoxaden. According to the preparation method disclosed by the invention, by adopting a catalyst with low price, the production cost is reduced; besides, hydrogen peroxide-alkali is adopted in a preparation process to serve as a hydrolyzed system, so that environmental pollution is greatly reduced.