314042-01-8 Usage
Uses
Used in Pharmaceutical Industry:
CID-1067700 is used as a novel GTPase inhibitor for targeting the Ras family of GTPases, which are involved in the regulation of cellular processes such as membrane trafficking and cell proliferation. Its ability to bind the nucleotide binding pocket of Rab7 with high affinity makes it a potential therapeutic agent for treating cancers and genetic diseases associated with alterations in GTPase function.
Used in Cancer Research:
CID-1067700 is used as a research tool in cancer research to study the role of Ras-related GTPases in tumor growth and progression. By inhibiting the nucleotide binding of these proteins, it can provide valuable insights into the development of targeted therapies for various types of cancer.
Used in Drug Development:
CID-1067700 serves as a lead compound in the development of new drugs targeting Ras-related GTPases. Its high affinity for the nucleotide binding pocket of Rab7 makes it a promising starting point for the design and synthesis of more potent and selective inhibitors for therapeutic applications in cancer and other diseases.
Biochem/physiol Actions
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases that potently binds to Rab7 nucleotide binding site.
References
Agola et al. (2012), A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition; ACS Chem. Biol., 7 1095
Agola et al. (2015), Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein; Methods Mol. Biol., 1298 331
Lam et al. (2016), Small Molecule Inhibition of Rab7 Impairs B Cell Switching and Plasma Cell Survival To Dampen the Autoantibody response in Murine Lupus; J. Immunol., 197 3792
Ghosh et al. (2020), ?-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway; Cell, 183 1520
Check Digit Verification of cas no
The CAS Registry Mumber 314042-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,4,0,4 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 314042-01:
(8*3)+(7*1)+(6*4)+(5*0)+(4*4)+(3*2)+(2*0)+(1*1)=78
78 % 10 = 8
So 314042-01-8 is a valid CAS Registry Number.
314042-01-8Relevant academic research and scientific papers
Rab7 GTPase inhibitors and related methods of treatment
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Page/Page column, (2014/07/08)
This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.
