314068-11-6

Basic information

• Product Name: N-[6-(6,7-bis-benzyloxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide
• CAS NO: 314068-11-6
• Molecular Weight: 799.003
• Mol File: 314068-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[6-(6,7-bis-benzyloxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[6-(6,7-bis-benzyloxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide(314068-11-6)
• EPA Substance Registry System: N-[6-(6,7-bis-benzyloxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide(314068-11-6)

Safety Data

• Hazardous Substances Data: 314068-11-6(Hazardous Substances Data)

Upstream product

• 241467-60-7 (6-{[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-methoxy}-naphthalen-2-yl)-carbamic acid tert-butyl ester 
• 314068-09-2 (6-chlorocarbonylmethoxy-naphthalen-2-yl)-carbamic acid tert-butyl ester 
• 64847-49-0 6-Hydroxynaphth-2-ylcarbamic acid, 1,1-dimethylethyl ester 
• 1699-56-5 2-(3,4-bis (phenylmethoxy)phenyl)ethylamine hydrochloride 

Relevant articles and documents

Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human β3 adrenergic receptor agonists

Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human β3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the β3 AR. Naphthyloxy compound 18 (β3 EC50 = 78 nM) did not activate the β1 and β2 ARs at 10 μM, and showed >1000-fold selectivity over binding to the β1 and β2 ARs. (C) 2000 Elsevier Science Ltd.