31418-71-0 Usage
Uses
Used in Microbial Infections:
Coprogen is used as an iron-scavenging molecule in pathogenic microorganisms for [application reason] obtaining essential iron from the host's environment. This ability to bind and transport iron is considered a key virulence factor, as it enables the invading microorganisms to out-compete the host's cells for this vital nutrient, thereby facilitating their growth, survival, and proliferation within the host.
Used in Cancer Therapy:
Coprogen is used as a potential therapeutic agent in cancer treatment for [application reason] its iron-binding ability. Some studies suggest that the high affinity of coprogen for iron could be exploited in the development of novel cancer therapies, possibly by disrupting the iron metabolism of cancer cells and inhibiting their growth. Further research is needed to fully understand the potential of coprogen in this context and to develop effective therapeutic strategies based on its properties.
Check Digit Verification of cas no
The CAS Registry Mumber 31418-71-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,4,1 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 31418-71:
(7*3)+(6*1)+(5*4)+(4*1)+(3*8)+(2*7)+(1*1)=90
90 % 10 = 0
So 31418-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C35H53N6O13.Fe/c1-23(11-17-42)20-30(45)39(51)14-5-8-27-33(48)38-28(34(49)37-27)9-6-15-40(52)32(47)22-25(3)13-19-54-35(50)29(36-26(4)44)10-7-16-41(53)31(46)21-24(2)12-18-43;/h20-22,27-29,42-43H,5-19H2,1-4H3,(H,36,44)(H,37,49)(H,38,48);/q-3;+3/b23-20-,24-21+,25-22-;
31418-71-0Relevant academic research and scientific papers
Wong, Geoffrey B.,Kappel, Mary J.,Raymond, Kenneth N.,Matzanke, B.,Winkelmann, G.
, p. 810 - 815 (1983)
The physical and thermodynamic properties of corpogen and ferricrocin, two hydroxamate siderophores produced by the fungus Neurospora crassa, have been examined.Formation constants determined by ethylenediaminetetraacetic acid (EDTA) competition reactions yielded the values logK* = 4.6 and 3.3 and logβ110 ca. 30.2 and 30.4, respectively, where K* = (3)/(3+>) and β110 = /(3+>3->), showing that these siderophores possess affinities for ferric ion similar to other hydroxamate ligands.Redox potentials of -447 and -412 mV vs.NHE, respectively, were found.Circular dichroism measurements have demonstrated that coprogen adopts primarily a Δ absolute configuration about the iron, whereas ferricrocin exists as the Λ isomer.
