314254-97-2Relevant academic research and scientific papers
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
Kozlowski, Joseph A,Lowe, Derek B.,Guzik, Henry S.,Zhou, Guowei,Ruperto, Vilma B.,Duffy, Ruth A.,McQuade, Robert,Crosby Jr., Gordon,Taylor, Lisa A.,Billard, William,Binch III, Herbert,Lachowicz, Jean E.
, p. 2255 - 2257 (2007/10/03)
Structure-activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-α-[4-[[4-methoxyphenyl](S)-sulfinyl]phenyl]-1-piperazineacetoni trile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold. (C) 2000 Elsevier Science Ltd.
